甲巯咪唑联合^(131)I对甲状腺功能亢进患者甲状腺动脉和肝动脉血流的影响  

Effect of Methimazole combined with ^(131)I on the blood flow of thyroid artery and hepatic artery in patients with hyperthyroidism

作　　者：赵亮[1] 曲静[1] ZHAO Liang;QU Jing(Department of Endocrinology,Dalian Second People′s Hospital,Liaoning Province,Dalian116000,China)

机构地区：[1]大连市第二人民医院内分泌科,辽宁大连116000

出　　处：《中国当代医药》2022年第25期108-110,114,共4页China Modern Medicine

摘　　要：目的探讨甲巯咪唑联合^(131)I对甲状腺功能亢进患者甲状腺动脉和肝动脉血流的影响。方法选取2019年1月至2020年12月大连市第二人民医院收治的90例甲状腺功能亢进患者作为研究对象,采用随机数字表法分为对照组和研究组,每组各45例。对照组给予甲巯咪唑治疗,研究组在对照组的基础上给予^(131)I治疗。比较两组患者治疗前后的甲状腺动脉和肝动脉血流动力学指标,包括平均流速(V_(m))、舒张末期流速(V_(min))、收缩峰流速(V_(max))、阻力指数(RI)、搏动指数(PI)。结果治疗前,两组患者的甲状腺和肝动脉血流动力学指标比较,差异无统计学意义(P>0.05)。治疗后,研究组的甲状腺动脉V_(m)、V_(min)、V_(max)低于对照组,差异有统计学意义(P<0.05);而两组患者的甲状腺动脉RI、PI比较,差异无统计学意义(P>0.05)。治疗后,研究组的肝动脉V_(m)、V_(min)、V_(max)低于对照组,差异有统计学意义(P<0.05),而两组患者的肝动脉RI、PI比较,差异无统计学意义(P>0.05)。结论相较于单独口服甲巯咪唑,甲状腺功能亢进患者口服甲巯咪唑和^(131)I对于甲状腺动脉和肝动脉血流的改善效果更好,值得推广应用。Objective To investigate the effect of Methimazole combined with ^(131)I on thyroid artery and hepatic artery blood flow in patients with hyperthyroidism.Methods A total of 90 patients with hyperthyroidism admitted to Dalian Second People′s Hospital from January 2019 to December 2020 were selected as the research subjects.They were divided into control group and research group by random number table method,with 45 cases in each group.The control group was given Methimazole treatment,and the research group was given ^(131)I treatment on the basis of the control group.The hemodynamics indexes of thyroid artery and hepatic artery were compared between two groups before and after treatment,including mean flow rate(V_(m)),end diastolic flow rate(V_(min)),peak systolic flow rate(V_(max)),resistance index(RI)and pulsatile index(PI).Results Before treatment,there was no significant difference in thyroid and hepatic arterial hemodynamics indexes between two groups(P>0.05).After treatment,the thyroid artery V_(m),V_(min) and V_(max) in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in thyroid artery RI and PI between the two groups(P>0.05).After treatment,V_(m),V_(min) and V_(max) of hepatic artery in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in hepatic artery RI and PI between the two groups(P>0.05).Conclusion Compared with oral Methimazole alone,oral Methimazole and ^(131)I can improve the blood flow of thyroid artery and hepatic artery in hyperthyroidism patients,which is worthy of promotion.

关 键 词：甲巯咪唑 ^(131)I 甲状腺功能亢进 血流动力学 

分 类 号：R581[医药卫生—内分泌]