门诊健康体检妇女人乳头瘤病毒宫颈感染状况及持续性感染影响因素  

Prevalence of cervical huma papillomavirus infection among women receiving physical examination in outpatient department and influencing factors for persistent infection

作　　者：任璐 曹芹雪 杨少琴 张冬丽 王宁 REN Lu;CAO Qin-xue;YANG Shao-qin;ZHANG Dong-li;WANG Ning(Huaihe Hospital of Henan University,Kaifeng,Henan 475004,China)

机构地区：[1]河南大学淮河医院妇产科,河南开封475004

出　　处：《中华医院感染学杂志》2022年第10期1560-1563,共4页Chinese Journal of Nosocomiology

基　　金：河南省教育厅科学技术研究基金资助项目(17A320023)。

摘　　要：目的 探讨门诊健康体检妇女人乳头瘤病毒(HPV)宫颈感染状况及持续性感染影响因素。方法 选择2019年1-12月于河南大学淮河医院门诊进行健康体检妇女为研究对象,收集体检妇女的流行病学调查问卷、宫颈液基薄层细胞检测(TCT)、宫颈上皮脱落细胞HPV分型检测。采用单因素及多因素Logistic分析高危型人乳头瘤病毒宫颈持续性感染影响因素。结果 10 472份HPV分型检查样本中阳性率为25.6%(2 685/10 472)。人乳头瘤病毒初筛阳性2 685例,随访2次后发现持续感染530例,持续感染率为19.7%,检出高危型人乳头瘤病毒阳性患者2 208例,其中持续性感染479例,持续感染率为21.7%。单因素分析结果,不同年龄、不同初次性生活年龄、不同避孕方式、不同性交频率、吸烟史、阴道宫颈炎症、性交后清洗是高危型人乳头瘤病毒宫颈持续性感染的影响因素(P<0.05)。多因素分析结果显示,年龄>50岁、非避孕套避孕是高危型人乳头瘤病毒宫颈持续性感染的独立危险因素。结论 河南大学淮河医院门诊健康体检妇女人乳头瘤病毒感染最为常见的亚型为HPV16、HPV58、HPV52,年龄>50岁、非避孕套避孕是高危型人乳头瘤病毒宫颈持续性感染的独立危险因素。OBJECTIVE To explore the prevalence of cervical human papillomavirus(HPV) infection among women receiving physical examination in outpatient department and analyze the influencing factors for persistent infection. METHODS The women who received physical examination in outpatient department of the Huaihe Hospital of Henan University from Jan 2019 to Dec 2019 were recruited as the study objects. The epidemiological survey questionnaires were collected from the women, the cervical fluid-based thin cell testing(TCT) was carried out, the types of HPV were detected for cervical epithelial exfoliated cells. Univariate analysis and multivariate logistic analysis were performed for the influencing factors for the persistent infection of high-risk HPV. RESULTS Among 10472 samples tested for types of HPV, the positive rate was 25.6%(2685/10472). 2685 women were positive for first screening of HPV, and 530 women had persistent infection after 2 times of follow-up, with the incidence of persistent infection 19.7%. Totally 2208 patients were tested positive for high-risk HPV, 479 of whom had persistent infection, with the incidence of persistent infection 21.7%. The result of univariate analysis showed that the age, age of sexual intercourse for the first time, contraceptive method, frequency of sexual intercourse, smoking history, vaginal cervical inflammation and cleaning after sexual intercourse were influencing factors for the persistent cervical high-risk HPV infection(P<0.05). The result of multivariate analysis indicated that more than 50 years of age and contraception without use of condom were the independent risk factors for the persistent cervical high-risk HPV infection. CONCLUSION HPV16, HPV58 and HPV52 are the most common subtypes of HPV that are detected in the women who receive physical examination in outpatient department of the Huaihe Hospital of Henan University. The more than 50 years of age and contraception without use of condom are the independent risk factors for the persistent cervical high-risk HPV in

关 键 词：健康体检 人乳头瘤病毒 宫颈感染 持续性感染 影响因素 

分 类 号：R711.32[医药卫生—妇产科学]