机械通气患者呼出气冷凝液检测研究进展  

Research progress on detection of exhaled breath condensate in patients underwent mechanically ventilated

作　　者：易娟 吴振超 王飞[2] 卢庆彬[3] 沈宁[2,4] YI Juan;WU Zhen-chao;WANG Fei;LU Qing-bin;SHEN Ning(Peking University Health Science Center,Beijing 10019l,China;不详)

机构地区：[1]北京大学医学部医学技术研究院,北京100191 [2]北京大学第三医院呼吸与危重症医学科,北京100191 [3]北京大学公共卫生学院卫生检验学系&疫苗评价中心,北京100191 [4]北京大学第三医院感染疾病中心,北京100191

出　　处：《中华医院感染学杂志》2022年第11期1756-1760,共5页Chinese Journal of Nosocomiology

基　　金：国家重点研发计划基金资助项目(2021YFC0122405);国家自然科学基金资助项目(82073617);北京市临床重点专科项目基金资助项目(010071);北京市自然科学基金-海淀原始创新联合基金资助项目(L202007)。

摘　　要：呼出气冷凝液(EBC)是呼出气与相对低温的表面接触冷却后获得的液体或固体形式的呼吸道标本,含有多种炎症、氧化应激标志物,并可携带病毒、细菌等病原体,是判断肺部炎症的有效手段之一,已被广泛应用于免疫、炎症性疾病的临床研究。机械通气是改善危重患者通气和氧合的一种生命支持方式,但存在导致呼吸机相关性肺损伤和呼吸机相关性肺炎等并发症的风险。呼出气冷凝液采集方便、实时、安全,在机械通气患者中可以用于早期识别肺部炎症或微生态改变,具有很大的应用潜力。本文从机械通气患者呼出气冷凝液常见检测项目及其临床应用两方面予以综述,以便更好地利用这一技术,为疾病的诊断、预测、评估提供新思路。Exhaled breath condensate(EBC)is a liquid or solid respiratory specimen obtained after exhaled gas is cooled in contact with a relatively low-temperature surface.It contains a variety of markers of inflammation and oxidative stress,can carry pathogens such as viruses and bacteria,is one of the effective means to elevate pulmonary inflammation,and has been widely used in the clinical research of immune and inflammatory diseases.Mechanical ventilation is a way of life support to improve ventilation and oxygenation in critically ill patients,but there is a risk of complications such as ventilator-induced lung injury and ventilator-associated pneumonia.The EBC can be used for early identification of pulmonary inflammation or microecological changes in mechanically ventilated patients and has great application potential due to its convenience,real-time,and safety of collection.This article reviewed the common detection items and clinical application of EBC in mechanically ventilated patients,in order to make better use of this technique and provide new ideas for the diagnosis,prediction and evaluation of diseases in mechanically ventilated patients.

关 键 词：呼出气冷凝液 机械通气 急性呼吸窘迫综合征 呼吸机相关性肺损伤 呼吸机相关性肺炎 

分 类 号：R454[医药卫生—治疗学]