富马酸贝达喹啉片联合盐酸乙胺丁醇治疗耐多药肺结核的临床疗效分析  

Clinical efficacy analysis of bedaquiline fumarate tablets combined with ethambutol hydrochloride in the treatment of multidrug-resistant pulmonary tuberculosis

作　　者：李艳丽 刘伟娟 LI Yan-li;LIU Wei-juan(Nursing Department,Shandong Provincial Public Health Clinical Center,Jinan 250013,China)

机构地区：[1]山东省公共卫生临床中心护理部,250013 [2]山东省公共卫生临床中心病案室,250013

出　　处：《中国实用医药》2022年第18期41-45,共5页China Practical Medicine

基　　金：山东省医药卫生科技发展计划(项目编号:2017WS290)项目名称:基于个体防护角度的结核职业感染现况及风险因素研究。

摘　　要：目的 分析富马酸贝达喹啉片联合盐酸乙胺丁醇对耐多药肺结核的临床疗效。方法 60例耐多药肺结核患者,随机分为观察组与对照组,各30例。对照组患者采用耐多药肺结核标准化疗方案,观察组在对照组的基础上加用富马酸贝达喹啉片联合盐酸乙胺丁醇治疗。比较两组治疗效果、不良反应发生率、痰菌阴转率、病灶吸收率、空洞闭合率、生活质量评分。结果 观察组治愈率为86.67%,高于对照组的56.67%,差异有统计学意义(P<0.05)。观察组不良反应发生率为13.33%,与对照组的10.00%比较,差异无统计学意义(P>0.05)。治疗6周,两组痰菌阴转率比较差异无统计学意义(P>0.05);治疗12、24周,观察组痰菌转阴率分别为70.00%、96.67%,均高于对照组的40.00%、73.33%,差异有统计学意义(P<0.05)。治疗6、12周,两组病灶吸收率比较差异无统计学意义(P>0.05);治疗24周,观察组病灶吸收率为93.33%,高于对照组的70.00%,差异有统计学意义(P<0.05)。治疗6、12周,两组空洞闭合率比较差异无统计学意义(P>0.05);治疗24周,观察组空洞闭合率为83.33%,高于对照组的60.00%,差异有统计学意义(P<0.05)。观察组活力、躯体功能、生理职能、一般健康、社会功能、精神健康、情绪角色评分分别为(76.29±1.31)、(90.77±2.09)、(68.19±1.18)、(66.61±2.52)、(81.51±1.42)、(82.82±1.71)、(75.61±1.28)分,均高于对照组的(66.22±1.31)、(82.79±2.22)、(57.52±1.33)、(59.71±2.41)、(73.49±2.27)、(70.68±1.88)、(61.22±1.39)分,差异有统计学意义(P<0.05)。结论 富马酸贝达喹啉片联合盐酸乙胺丁醇对耐多药肺结核具有良好的治疗效果,能明显提高患者的治愈率、病灶吸收率、痰菌转阴率、空洞闭合率、安全性,对于促使患者的生活质量提高具有显著的作用。Objective To analyze the clinical efficacy of bedaquiline fumarate tablets combined with ethambutol hydrochloride in the treatment of multidrug-resistant pulmonary tuberculosis. Methods A total of 60 patients with multidrug-resistant pulmonary tuberculosis were randomly divided into observation group and control group, with 30 cases in each group. Patients in the control group were treated with the standard chemotherapy regimen of multidrug-resistant pulmonary tuberculosis, and patients in the observation group were additionally treated with bedaquiline fumarate tablets combined with ethambutol hydrochloride on the basis of the control group. The therapeutic effect, incidence of adverse reactions, sputum negative-conversion rate, lesion absorption rate, cavity closure rate, and quality of life scores were compared between the two groups. Results The cure rate of the observation group was 86.67%, which was higher than 56.67% of the control group, and the difference was statistically significant(P<0.05). The incidence of adverse reactions in the observation group was 13.33%, which was not statistically significant compared with 10.00% in the control group(P>0.05). After 6 weeks of treatment, there was no statistically significant difference in sputum negative-conversion rate between the two groups(P>0.05). After 12 and 24 weeks of treatment, the sputum negative-conversion rate in the observation group were 70.00% and 96.67%, which were higher than 40.00% and 73.33% in the control group, and the differences were statistically significant(P<0.05). After 6 and 12 weeks of treatment, there was no statistically significant difference in the lesion absorption rate between the two groups(P>0.05). After 24 weeks of treatment, the lesion absorption rate in the observation group was 93.33%, which was higher than 70.00% in the control group, and the difference was statistically significant(P<0.05). After 6 and 12 weeks of treatment, there was no statistically significant difference in the cavity closure rate between the two g

关 键 词：富马酸贝达喹啉片 盐酸乙胺丁醇 耐多药肺结核 临床疗效 不良反应 

分 类 号：R521[医药卫生—内科学]