分析小儿先天性心脏病合并心力衰竭外周血NT-proBNP、cTnI、CRP水平变化及其临床意义  

Analysis of changes of NT-proBNP, cTnI and CRP levels in peripheral blood and their clinical significance in pediatric congenital heart disease combined with heart failure

作　　者：王辉[1] 付红彬 吴海波[1] 孙婷婷 WANG Hui;FU Hong-bin;WU Hai-bo(Department of Pediatrics,Maternal and Child Health Hospital,Zaozhuang 277100,China)

机构地区：[1]山东省枣庄市妇幼保健院儿科,277100

出　　处：《中国实用医药》2022年第18期96-98,共3页China Practical Medicine

摘　　要：目的 探究小儿先天性心脏病合并心力衰竭(HF)患儿外周血氨基末端脑利钠肽前体(NT-proBNP)、肌钙蛋白I(cTnI)、C反应蛋白(CRP)水平变化情况,并分析其临床意义。方法 选取56例小儿先天性心脏病合并HF患儿作为观察组,另选取56例健康儿童作为对照组;将观察组患儿根据HF严重程度不同分为轻度HF组(20例)与中重度HF组(36例)。所有受检者均应用免疫层析法检验NT-proBNP水平,应用酶联免疫吸附试验(ELISA)检验c TnI、CRP水平。比较观察组与对照组、观察组中轻度HF组与中重度HF组的NT-proBNP、cTnI、CRP水平。结果 观察组的NT-proBNP、cTnI、CRP水平分别为(188.35±35.20)ng/L、(0.08±0.03)ng/ml、(16.42±2.13)mg/L,均显著高于对照组的(93.21±20.45)ng/L、(0.02±0.01)ng/ml、(3.62±0.26)mg/L,差异具有统计学意义(P<0.05)。轻度HF组患儿NT-proBNP、cTnI、CRP水平分别为(143.24±23.41)ng/L、(0.06±0.03)ng/ml、(11.24±2.10)mg/L,均低于中重度HF组的(213.41±30.08)ng/L、(0.09±0.01)ng/ml、(19.30±3.22)mg/L,差异具有统计学意义(P<0.05)。结论 与正常儿童相比,小儿先天性心脏病合并HF患儿的外周血NT-proBNP、cTnI、CRP水平相对较高,且患儿HF越严重,以上三项指标水平越高。Objective To investigate the changes of N-terminal pro-B-type natriuretic peptide(NT-proBNP), cardiac troponin I(cTnI) and C-reactive protein(CRP) levels in peripheral blood in pediatric congenital heart disease combined with heart failure(HF), and analyze their clinical significance. Methods 56 children with congenital heart disease and HF were selected as the observation group, and 56 healthy children were selected as the control group;the children in the observation group were divided into mild HF group(20 cases) and moderate-severe HF group(36 cases) according to the severity of HF. All subjects were tested by immunochromatography to detect the level of NT-proBNP, and by enzyme-linked immunosorbent assay(ELISA)to detect the levels of cTnI and CRP. The levels of NT-proBNP, cTnI and CRP were compared between the observation group and the control group, the mild HF group and the moderate-severe HF group in the observation group. Results The levels of NT-proBNP, cTnI and CRP in the observation group were(188.35±35.20) ng/L,(0.08±0.03) ng/ml and(16.42±2.13) mg/L, which were significantly higher than(93.21±20.45) ng/L,(0.02±0.01) ng/ml and(3.62±0.26) mg/L in the control group, and the differences were statistically significant(P<0.05). The levels of NT-proBNP, cTnI and CRP in the mild HF group were(143.24±23.41) ng/L,(0.06±0.03) ng/ml and(11.24±2.10) mg/L, which were lower than(213.41±30.08) ng/L,(0.09±0.01) ng/ml and(19.30±3.22) mg/L in the moderate-severe HF group, and the differences were statistically significant(P<0.05).Conclusion Compared with normal children, the levels of NT-proBNP, cTnI and CRP in peripheral blood of children with congenital heart disease complicated with HF are relatively higher, and the more severe the HF, the higher the levels of the above three indicators.

关 键 词：小儿先天性心脏病 心力衰竭 外周血氨基末端脑利钠肽前体 肌钙蛋白I C反应蛋白 

分 类 号：R725.4[医药卫生—儿科]