HFHD联合西沙必利对慢性CRF患者的炎症因子、肾功能指标及临床疗效分析  

Analysis of effect of HFHD combined with cisapride on inflammatory factors,renal function indexes and clinical efficacy in patients with chronic CRF

作　　者：高艳玲 GAO Yan-ling(Department of Emergency,Central Hospital of Handan City,Hebei Province,Handan 056001,China)

机构地区：[1]河北省邯郸市中心医院急诊科,河北邯郸056001

出　　处：《河北医科大学学报》2022年第8期909-914,共6页Journal of Hebei Medical University

基　　金：河北省健康卫生健康委员会(20220023)。

摘　　要：目的分析探讨高通量血液透析(high throughput hemodialysis,HFHD)联合西沙必利对慢性肾功能衰竭(chronic renal failure,CRF)患者的炎症因子、肾功能指标及临床疗效。方法收集152例CRF患者为治疗对象,随机抽签法分为观察组、对照组,各76例。对照组以HFHD治疗,观察组在对照组基础上联合西沙必利(必利)治疗。对两组患者的炎症因子、肾功能指标、胃肠激素、临床疗效、治疗安全性等指标进行评估比较。结果治疗后观察组患者的降钙素基因相关肽(calcitonin gene related peptide,CGRP)、血清成纤维细胞生长因子23(serum fibroblast growth factor 23,FGF-23)、热休克蛋白47(heat shock protein 47,HSP47)水平均低于对照组(P<0.05)。治疗后观察组肾功能指标β2-微球蛋白(β2-microglobulin,β2-MG)、尿素氮(urea nitrogen,BUN)、血清肌酐(serum creatinine,Scr)水平均低于对照组(P<0.05)。治疗后观察组患者的胃泌素(gastrin,GAS)、血管活性肠肽(vasoactive intestinal peptide,VIP)、胃动素(motilin,MOT)水平均高于对照组(P<0.05)。治疗后观察总有效率为92.11%(70/76),高于对照组患者80.26%(61/76)(P<0.05)。治疗期间两组患者不良反应发生率分别为14.47%(11/76)、10.53%(8/76)(P>0.05)。结论HFHD联合西沙必利对慢性CRF患者治疗效果显著,能够降低患者的炎性反应水平,改善患者的胃肠激素水平,提高患者的肾功能,治疗安全性较好。Objective To analyze the effect of high flux hemodialysis(HFHD)combined with cisapride on inflammatory factors,renal function indexes and clinical efficacy in patients with chronic renal failure(CRF).Methods A total of 152 patients with CRF who were treated were enrolled,and randomly divided into observation group(n=76)and control group(n=76).The control group was treated with HFHD,and the observation group was treated with cisapride on the basis of the control group.The inflammatory factors,renal function indexes,gastrointestinal hormones,clinical efficacy and treatment safety of the two groups were evaluated and compared.Results After treatment,the levels of calcitonin gene-related peptide(CGRP),serum fibroblast growth factor 23(FGF-23)and heat shock protein 47(HSP47)in the observation group were lower than those in the control group(P<0.05).After treatment,renal function indexes[β2-microglobulin(β2-MG),urea nitrogen(BUN)and serum creatinine(Scr)]in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of gastrin(GAS),vasoactive intestinal peptide(VIP)and motilin(MOT)in the observation group were higher than those in the control group(P<0.05).After treatment,the total effective rate was 92.11%(70/76),which was higher than that[80.26%(61/76)]in the control group(P<0.05).The incidence of adverse reactions in the two groups were 14.47%(11/76)and 10.53%(8/76)respectively(P>0.05).Conclusion HFHD combined with cisapride is effective in the treatment of patients with chronic CRF.It can reduce the level of inflammatory reaction,and improve the level of gastrointestinal hormone and the renal function,with good safety.

关 键 词：肾功能衰竭 慢性 肾透析 炎症因子 

分 类 号：R692.5[医药卫生—泌尿科学]