养心饮汤增减对老年急性冠脉综合征经皮冠状动脉介入术后外周血CD40、NF-κB表达的影响  

Effect of Yangxinyin Decoction(养心饮汤)on Expressions of CD40 and NF-κB in Peripheral Blood of Elderly Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention

作　　者：张艳红[1] 崔萌[1] 江宁[1] ZHANG Yanhong;CUI Meng;JIANG Ning(Jinan Hospital of Traditional Chinese Medicine,Jinan 250012,Shandong,China)

机构地区：[1]济南市中医医院,山东济南250012

出　　处：《中华中医药学刊》2022年第7期71-73,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家科技部科技基础性工作专项基金(2019FY7961031);山东省中医药科技发展计划(2019-0555);济南市卫生健康委员会第二批科技计划(2020-4-60);济南市卫生健康委员会科技计划(2021-中-28)。

摘　　要：目的探究分析养心饮汤增减对老年急性冠脉综合征经皮冠状动脉介入(PCI)术后患者外周血CD40、NF-κB表达的影响。方法选择2019年1月—2021年1月于医院心内科就诊的60例确诊急性冠脉综合征拟行经皮冠状动脉介入术的老年女性患者作为本次研究对象,按照随机数字表法随机分为试验组30例和对照组30例,全部患者行标准化PCI手术,对照组患者PCI术后给予常规氯吡格雷、阿司匹林肠溶片口服治疗,试验组患者在对照组基础上术后给予养心饮汤,持续治疗2周。对比两组患者术后采取药物治疗前后血清CD40、NF-κB水平,依据患者经过治疗后的临床表现及心电图等辅助检查情况进行疗效评价,对比两组患者术后并发症及不良事件发生情况。结果治疗前,两组患者血清CD40、NF-κB等细胞因子水平差异不具有统计学意义(P>0.05);治疗后,两组患者血清CD40、NF-κB等细胞因子水平均低于治疗前,试验组血清CD40、NF-κB均低于对照组,差异有统计学意义(P<0.05)。两组患者术后经不同方法干预后,试验组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。试验组患者术后不良事件发生率低于对照组,差异有统计学意义(P<0.05)。结论养心饮汤增减治疗老年急性冠脉综合征经皮冠状动脉介入术后患者可以显著降低外周血CD40、NF-κB表达,促进术后恢复,降低不良事件发生。Objective To explore and analyze the effect of Yangxinyin Decoction(养心饮汤)on the expressions of CD40 and nuclear factor kappa-B(NF-κB)in peripheral blood of elderly patients with acute coronary syndrome after percutaneous coronary intervention(PCI).Methods Sixty elderly female patients who were diagnosed as acute coronary syndrome and planned to undergo percutaneous coronary intervention in the cardiology department of the hospital between January 2019 and January 2021 were selected as the subjects of this study.According to the random number table method,they were randomly divided into the experimental group(30 cases)and the control group(30 cases).All patients underwent standardized PCI surgery.Patients in the control group were given conventional clopidogrel and aspirin enteric-coated tablets after PCI.Patients in the experimental group were given Yangxinyin Decoction on the basis of the control group.Both two groups were treated for 2 weeks.The serum CD40 and NF-κB levels of the two groups of patients before and after the drug treatment were compared.The efficacy was evaluated based on the clinical manifestations of the patients.The auxiliary examinations such as electrocardiogram after treatment and the postoperative complications and adverse events of the two groups were compared.Results Before treatment,there was no significant difference in serum CD40,NF-κB or other cytokine levels between the two groups(P>0.05).After treatment,serum levels of CD40,NF-κB and other cytokines in two groups were lower than those before treatment,and serum levels of CD40 and NF-κB in the experimental group were lower than those in the control group.The difference was statistically significant(P<0.05).After different methods of postoperative intervention,the total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The incidence of postoperative adverse events in the experimental group was lower than that in the control group,an

关 键 词：养心饮汤 急性冠脉综合征 PCI 细胞因子 

分 类 号：R259.414[医药卫生—中西医结合]