健脾固肾方对脾肾亏虚型早期糖尿病肾病胰岛功能及肾功能的影响  

Effect of Jianpi Gushen Recipe(健脾固肾方)on Islet Function and Renal Function in Patients with Early Diabetic Nephropathy of Spleen-Kidney Deficiency Type

作　　者：吴平 邱晓堂 李赫男 吴英日 WU Ping;QIU Xiaotang;LI Henan;WU Yingri(Hainan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Chinese Medicine,Haikou 570203,Hainan,China)

机构地区：[1]广州中医药大学附属海南中医院,海南海口570203

出　　处：《中华中医药学刊》2022年第7期79-81,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药行业科研项目(20205673)。

摘　　要：目的健脾固肾方对脾肾亏虚型早期糖尿病肾病患者胰岛功能及肾功能的影响。方法随机将医院诊治的120例脾肾亏虚型早期糖尿病肾病患者分为对照组和观察组,两组各60例,对照组进行常规降糖、降压治疗,观察组在对照组的基础上给予健脾固肾方治疗,两组均治疗2个月。观察两组患者治疗前后临床疗效、中医证候积分、胰岛功能及肾功能改善情况。结果两组患者治疗4周后,观察组总有效率为91.67%(55/60),显著高于对照组的78.33%(47/60);治疗后,中医证候积分显著降低(P<0.05);且观察组改善显著优于对照组(P<0.05);胰岛素分泌指数(HOMA-β)水平显著低于同组治疗前(P<0.05),胰岛素抵抗指数(HOMA-IR)及空腹胰岛素(FINS)水平显著高于同组治疗前(P<0.05),观察组HOMA-β水平及HOMA-IR、FINS水平改善程度,均显著优于对照组(P<0.05);两组治疗后血肌酐(Scr)、血尿素氮(BUN)、尿白蛋白/肌酐比值(UACR)水平显著低于同组治疗前(P<0.05),肾小球滤过率(eGFR)水平显著高于同组治疗前(P<0.05);治疗后,观察组BUN、Scr、UAER水平显著低于对照组,肾小球滤过率水平显著高于对照组。结论健脾固肾方可显著提高脾肾亏虚型早期糖尿病肾病患者治疗效果,减少临床症状,并显著改善患者胰岛功能及肾功能。Objective To observe the effect of Jianpi Gushen Recipe(健脾固肾方)on pancreatic islet function and renal function in patients with early diabetic nephropathy of spleen-kidney deficiency type.Methods A total of 120 patients with early diabetic nephropathy of spleen-kidney deficiency type were randomly divided into a control group and a treatment group,with 60 cases in each group.The control group received conventional hypoglycemic and antihypertensive treatment,and the treatment group was treated with Jianpi Gushen Decoction on the basis of the control group,and the course of treatment was 2 months in both groups.The clinical efficacy,TCM syndrome score,islet function and renal function improvement of the two groups before and after treatment were observed.Results After 4 weeks of treatment,the total effective rate of the observation group was 91.67%,which was significantly higher than 78.33%(47/60)of the control group.The TCM syndrome score was significantly lower than that before treatment(P<0.05)and the TCM syndrome score of the observation group was improved significantly than that of the control group(P<0.05).The level of insulin secretion index(HOMA-β)after treatment was significantly lower than that of the same group before treatment(P<0.05),and the levels of insulin resistance index(HOMA-IR)and fasting insulin(FINS)were significantly higher than those before treatment in the same group(P<0.05).The improvements of HOMA-βlevels,HOMA-IR and FINS levels in the observation group were significantly better than those in the control group(P<0.05).After treatment,the serum levels of creatinine(Scr),urea nitrogen(BUN)and urine albumin/creatinine ratio(UACR)were significantly lower than those before treatment in the same group(P<0.05),and glomerular filtration rate(eGFR)levels were significantly higher than those before treatment in the same group(P<0.05).After treatment,the levels of BUN,Scr and UAER in the observation group were significantly lower than those in the control group,and the glomerular filtrati

关 键 词：健脾固肾方 脾肾亏虚 糖尿病肾病 胰岛功能 肾功能 

分 类 号：R259.872[医药卫生—中西医结合]