基于缺氧诱导线粒体自噬探讨补肺健脾通络法治疗慢性阻塞性肺疾病合并骨骼肌功能障碍机制  

Exploration on Mechanism of Tonifying Lung,Invigorating Spleen and Clearing Collaterals in Treatment of COPD Combined with Skeletal Muscle Dysfunction Based on Hypoxia-Induced Mitochondrial Autophagy

作　　者：王靖宇 崔钰伟 李品[2] 庞立健[2] 臧凝子[2] 吕晓东[1] WANG Jingyu;CUI Yuwei;LI Pin;PANG Lijian;ZANG Ningzi;LYU Xiaodong(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中华中医药学刊》2022年第7期87-90,I0033,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金(82004294);国家自然科学基金面上项目(81373579);辽宁省教育厅青年科技人才“育苗”项目(L202046);辽宁省科技厅重点项目(2019JH2/10300023);辽宁省“兴辽英才计划”高水平创新创业团队项目(XLYC1808011)。

摘　　要：慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)由于经济负担重、死亡率高等成为了全球范围内最重要的健康问题之一,给人类带来了巨大且日益增长的经济和社会负担,如何有效控制COPD已经成为待解决的重大难题。COPD患者常出现骨骼肌功能障碍,会严重影响患者的活动能力,同时也是引起患者生活质量低下的关键因素。随着对COPD合并骨骼肌功能障碍研究的不断深入,肺、脾、络始终贯穿疾病的发生与发展。线粒体是细胞内能量的重要来源,骨骼肌中含有丰富的线粒体,而缺氧诱导的线粒体自噬在维持线粒体数量以及质量中发挥重要作用。旨在从缺氧诱导线粒体自噬角度探讨补肺健脾通络法治疗COPD合并骨骼肌功能障碍的机制,在治疗骨骼肌功能障碍方面提供新思想和新方案。Chronic obstructive pulmonary disease(COPD)has become one of the most important health problems worldwide due to the large number of patients and high mortality rate,and has brought huge and growing economic and social burden to human beings.How to effectively control COPD has become a major problem to be solved.Skeletal muscle dysfunction often occurs in COPD patients,which severely affects exercise tolerance and is also a key factor leading to poor quality of life in patients.With the deepening of researches on COPD combined with skeletal muscle dysfunction,lung,spleen and collaterals are of great significance in the occurrence and development of diseases.Mitochondria are the important source of intracellular energy.Skeletal muscle is rich in mitochondria,and hypoxia-induced mitochondrial autophagy plays an important role in maintaining the quantity and quality of mitochondria.This study aims to explore the mechanism of tonifying lung,invigorating spleen and clearing collaterals in the treatment of COPD combined with skeletal muscle dysfunction from the perspective of hypoxia-induced mitochondrial autophagy,and provide new ideas and schemes for the treatment of skeletal muscle dysfunction.

关 键 词：COPD 骨骼肌功能障碍 线粒体自噬 缺氧 补肺健脾通络 

分 类 号：R285.5[医药卫生—中药学]