脑心通胶囊对脑卒中气虚血瘀证rt-PA静脉溶栓后静脉血S100b蛋白表达、学习记忆及肢体运动功能的影响研究  

Effect of Naoxintong Capsule(脑心通胶囊)on Expression of S100b Protein in Venous Blood,Learning and Memory and Limb Motor Function after rt-PA Intravenous Thrombolysis of Stroke of Qi Deficiency and Blood Stasis Syndrome

作　　者：黄启勇 覃瑞明 文润嘉 廖宝共[2] HUANG Qiyong;QIN Ruiming;WEN Runjia;LIAO Baogong(Laibin Hospital of Traditional Chinese Medicine,Laibin 546100,Guangxi,China;The First Affiliated Hospital of Guangxi University of Science and Technology,Liuzhou 545000,Guangxi,China)

机构地区：[1]来宾市中医医院,广西来宾546100 [2]广西科技大学第一附属医院,广西柳州545000

出　　处：《中华中医药学刊》2022年第7期237-240,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：广西壮族自治区中医药管理局自筹经费科研项目(GZZC2020354)。

摘　　要：目的探讨脑心通胶囊在脑卒中气虚血瘀证采用溶栓药物进行静脉溶栓患者中应用后对静脉血S100b蛋白表达、学习记忆和肢体运动功能指标的影响。方法将医院2018年11月—2020年11月收治的120例气虚血瘀型脑卒中患者作为研究对象,且均经rt-PA静脉溶栓治疗。按照患者入院先后顺序及意愿,将患者分为观察组与对照组,各60例。对照组溶栓后采用常规治疗方式,观察组患者则口服脑心通胶囊进行治疗,2周为1个疗程,连续治疗2个疗程。比较两组患者血清sICAM-1、S100b蛋白水平的变化,肢体运动功能指标[Fugl-Meyer运动量表(FMMS)和步行能力]评分变化,气虚血瘀证症状变化评分以及记忆功能(韦式记忆量表)评分变化。结果(1)治疗前两组血清SICAM-1及S100b蛋白水平比较无统计学意义(P>0.05),治疗后指标水平均降低,但观察组患者降低水平与对照组患者比较更加显著,比较差异有统计学意义(P<0.05);(2)治疗后观察组与对照组上肢FMMS、下肢FMMS及步行能力比较评分变化更加显著(P<0.05);(3)治疗后气虚血瘀症状指标(气短乏力、面色苍白、便溏、舌质黯)观察组评分降低程度与对照组比较差异有统计学意义(P<0.05);(4)治疗后观察组记忆功能(1~100、100~1、累加、再认、再生、记图、联想、理解、触摸、背数)评分升高程度明显高于对照组(P<0.05)。结论脑心通胶囊用于溶栓后的气虚血瘀证脑卒中患者中,与常规治疗方式比较,在改善患者的记忆功能和肢体运动功能方面具有显著的效果,改善脑卒中气虚血瘀证的中医证候,降低血清sICAM-1水平,改善血管的“低灌注”和“不灌注”,降低血清S100bs蛋白水平,阻止了神经细胞的凋亡,减轻了患者脑损伤程度,对预后有改善。Objective To objective the effects of Naoxintong Capsule(脑心通胶囊)on the expression of S100 b protein in venous blood,learning and memory and limb motor function in stroke patients with Qi deficiency and blood stasis syndrome treated with throbolytic drugs.Method A total of 120 stroke patients with Qi deficiency and blood stasis type admitted to the hospital from November 2018 to November 2020 were selected as the research subjects,and all of them received intravenous recombinant tissue plasminogen activator(rt-PA)thrombolytic therapy.Patients were divided into the observation group and the control group according to their admission order and willingness,with 60 cases in each group.The control group was treated with conventional treatment after thrombolysis,and the observation group was treated with Naoxintong Capsule orally,2 weeks as a course of treatment,totally for 2 consecutive courses of treatment.The changes of serum human soluble intercellular adhesion molecule-1(sICAM-1)and recombinant S100 calcium binding protein B(S100 b)protein,the changes of limb motor function indexes[fugl-meyer movement scale(FMMS)and walking ability],the changes of symptoms of Qi deficiency and blood stasis syndrome and the changes of memory function(way-type memory scale)scores were compared between two groups.Results(1)Before treatment,the serum levels of sICAM-1 and S100 b protein in the two groups were not statistically significant(P>0.05),and the levels were decreased after treatment,but the reduced level in the observation group was more significant than that in the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the scores of upper limb FMMS,lower limb FMMS and walking ability increase of the observation group were more significant than those in the control group(P<0.05).(3)After treatment,the scores of symptom indicators of Qi deficiency and blood stasis(shortness of breath weakness,pale complexion,loose stool and dark tongue)were all decreased,and those in the observation g

关 键 词：脑心通胶囊 脑卒中 气虚血瘀证 静脉溶栓 学习记忆功能 肢体运动功能 

分 类 号：R255.2[医药卫生—中医内科学]