Using Methanol as a Formaldehyde Surrogate for Sustainable Synthesis of N-Heterocycles via Manganese-Catalyzed Dehydrogenative Cyclization  

作　　者：Zhihui Shao Shanshan Yuan Yibiao Li Qiang Liu 

机构地区：[1]Center of Basic Molecular Science(CBMS),Department of Chemistry,Tsinghua University,Beijing 100084,China [2]Flavors and Fragrance Engineering&Technology Research Center of Henan Province,College of Tobacco Science,Henan Agricultural University,Zhengzhou,Henan 450002,China [3]School of Biotechnology and Health Sciences,Wuyi University,Jiangmen,Guangdong 529090,China

出　　处：《Chinese Journal of Chemistry》2022年第10期1137-1143,共7页中国化学（英文版）

基　　金：This project was supported by the National Natural Science Foundation of China(Nos.91845107 and 21822106);the Foundation of the Department of Education of Guangdong Province(2018KZDXM070 and 2021KTSCX140)。

摘　　要：The development of an efficient and sustainable synthetic route for formaldehyde production from renewable feedstock,especially in combination with a subsequent transformation to straightforwardly construct valuable chemicals,is highly desirable.Herein,we report a novel manganese-catalyzed dehydrogenative cyclization of methanol as a formaldehyde surrogate with a variety of dinucleophiles for facile synthesis of N-heterocycles.The in situ generated formaldehyde via catalytic methanol dehydrogenation can be selectively trapped by diverse dinucleophiles to avoid several possible side reactions.The utilty of this transformation is further highlighted by its successful appliation to the synthesis of 13C-labeled N-heterocycles using 13CH_(3)OH as a readily accessible 13C-isotope reagent.

关 键 词：METHANOL DEHYDROGENATION Formaldehyde surrogate Manganese catalysis N-HETEROCYCLES 

分 类 号：O62[理学—有机化学]