Solvent-Regulated Diastereodivergent [3+2] Annulations of CF_(3)-Containing Morita-Baylis-Hillman Carbonates with Cyclic Sulfonimines  

作　　者：Bao-xin Liu Ru-Jie Yan Wei Du Ying-Chun Chen 

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu,Sichuan 610041,China [2]College of Pharmacy,Third Military Medical University,Shapingba,Chongqing 400038,China

出　　处：《Chinese Journal of Chemistry》2022年第10期1185-1189,共5页中国化学（英文版）

基　　金：We are grateful for the financial support from the NSFC(Nos.21931006 and 21921002);the Fundamental Research Funds for the Central Universities.

摘　　要：A solvent-regulated diastereodivergent[3+2]annulation reaction between Morita-Baylis-Hillman carbonates from aryl trifluoromethyl ketones and cyclic sulfonimines is developed under the catalysis of a modified cinchona alkaloid,furnishing diverse polycyclic products bearing vicinal quaternary stereogenic centers with outstanding enantioselectivity and moderate to high diastereoselectivity.

关 键 词：Diastereodivergent synthesis [3+2]annulation Trifluoromethyl group Lewis bases Solvent effects 

分 类 号：O62[理学—有机化学]