基于Chirp编码激励的微型介入式超声消融方法研究  

Study on an Internal Ultrasound Therapy Method Based on the Chirp-coded Excitation

作　　者：陈贝翼 宁传龙 张瑞[1,2] 黄文昌 徐杰 邵维维[2] 崔崤峣[2] CHEN Beiyi;NING Chuanlong;ZHANG Rui;HUANG Wenchang;XU Jie;SHAO Weiwei;CUI Yaoyao(School of Biomedical Engineering(Suzhou),Division of Life Sciences and Medicine,University of Science and Technology of China,Suzhou 215000,Jiangsu,P.R.China;Suzhou Institute of Biomedical Engineering and Technology,Chinese Academy of Sciences,Suzhou 215163,Jiangsu,P.R.China)

机构地区：[1]中国科学技术大学生物医学工程学院(苏州),生命科学与医学部,江苏苏州215000 [2]中国科学院苏州生物医学工程技术研究所,江苏苏州215163

出　　处：《影像科学与光化学》2022年第5期997-1003,共7页Imaging Science and Photochemistry

基　　金：江苏省重点研发计划(BE2021659);国家重点研发计划(2018YFB2000200);苏州市科技计划项目(SZS201903)。

摘　　要：超声消融是目前治疗肿瘤等疾病倍受关注的方法。为了在微创介入治疗情况下,尽可能扩大消融治疗区域、缩短治疗时长,文章提出一种基于Chirp编码激励的介入式超声消融方法,结合自主研制的微型化介入消融换能器和小型化Chirp编码激励电路模块,实验验证讨论了该方法的有效性。聚丙烯酰胺(PAA)仿体实验结果表明:相比于恒定频率激励方法,采用Chirp编码激励方法,可以在相同时间内扩大单次消融的有效治疗区域;在保证一定消融治疗覆盖面积的基础上,有效减少整体消融治疗时间。Ultrasound ablation is a method of treating cancer and other diseases which has received a lot of attention. The paper put forward an internal ultrasound therapy method based on Chirp-coded excitation which was studied in order to expand the therapeutic area and to reduce treatment duration. The self-made experimental platform and driving system were used in phantom experiments. The results of polyacrylamide(PAA) phantom experiments showed that, compared with constant-frequency excitation, Chirp-coded excitation can expand the effective treatment area of single ablation. On the basis of ensuring the range of ablation, the overall treatment duration can be effectively reduced.

关 键 词：介入超声 超声消融 信号调制 热效应 空化效应 

分 类 号：R445.1[医药卫生—影像医学与核医学]