TDI联合血清miR-34a在CHD合并PAH患儿诊断中的应用  

Application of TDI Combined with Serum miR-34a in the Diagnosis of Children CHD Complicated with PAH

作　　者：徐姗姗 曹仙英 周彬 XU Shanshan;CAO Xianying;ZHOU Bin(Department of Ultrasound Medicine,Shangrao Municipal Hospital,Shangrao 334000,Jiangxi,P.R.China;Department of Obstetrics and Gynecology,Shangrao Municipal Hospital,Shangrao 334000,Jiangxi,P.R.China)

机构地区：[1]上饶市立医院超声医学科,江西上饶334000 [2]上饶市立医院妇产科,江西上饶334000

出　　处：《影像科学与光化学》2022年第5期1039-1044,共6页Imaging Science and Photochemistry

摘　　要：本研究探讨组织多普勒超声心动图(TDI)联合血清microRNA-34a(miR-34a)在先天性心脏病(CHD)患儿合并肺动脉高压(PAH)诊断中的价值。根据是否发生PAH将112例CHD患儿分为CHD组和CHD+PAH组,均进行TDI检查,分别测量两组患儿的TDI-Tei和TDI-Z,并通过qRT-PCR检测患儿血清miR-34a水平。结果显示,CHD组的TDI-Tei显著低于CHD+PAH组(P<0.001),CHD组的TDI-Z显著高于CHD+PAH组(P<0.001);CHD组的血清miR-34a相对表达量显著低于CHD+PAH组(P<0.001)。相关性分析显示,TDI-Tei与TDI-Z呈负相关关系(r=-0.325,P<0.01),TDI-Tei与血清miR-34a呈正相关关系(r=0.260,P<0.01),TDI-Z与血清miR-34a呈负相关关系(r=-0.386,P<0.01)。TDI-Tei、TDI-Z和血清miR-34a联合诊断CHD合并PAH的AUC和敏感性高于单独诊断。TDI联合血清miR-34a在诊断CHD合并PAH中具有较高的价值,值得临床推广。This study explored the diagnostic value of Tissue Doppler Imaging(TDI)combined with serum microRNA-34a(miR-34a)in the diagnosis of children congenital heart disease (CHD)complicated with pulmonary arterial hypertension (PAH).According to the occurrence of PAH,all 112CHD children were divided into CHD group and CHD+PAH group and all of them underwent TDI examination.The TDI-Tei and TDI-Z of the two groups were measured respectively,and the serum miR-34alevel of the children was detected by qRT-PCR test.The results showed that the TDI-Tei of the CHD group was significantly lower than that of the CHD+PAH group(P<0.001),the TDI-Z of the CHD group was significantly higher than that of the CHD+PAH group(P<0.001),the relative expression of serum miR-34ain CHD group was significantly lower than that in CHD+PAH group(P<0.001).Correlation analysis showed that TDI-Tei was negatively correlated with TDI-Z(r=-0.325,P<0.01),TDI-Tei was positively correlated with serum miR-34a (r=0.260,P<0.01),TDI-Z was negatively correlated with serum miR-34a(r=-0.386,P<0.01).The AUC and the sensitivity of TDI-Tei,TDI-Z and serum miR-34acombined diagnosis of CHD complicated with PAH were higher than those of single diagnosis.In conclusion,TDI combined with serum miR-34ahas higher value in the diagnosis of CHD complicated with PAH,and was worthy of clinical promotion.

关 键 词：先天性心脏病 肺动脉高压 组织多普勒超声心动图 microRNA-34a TDI-Tei TDI-Z 

分 类 号：R725.4[医药卫生—儿科]