益补胃宝汤联合子午流注针法治疗慢性胃炎的效果  

Effect of Yibuweibao Decoction Combined with Ziwu Liuzhu Acupuncture on Treating Chronic Gastritis

作　　者：郝杰[1,3] 黄云曼 霍永利[1,3] 李博林[1,2] 孙润雪 尹璐[1] 陈贤 HAO Jie;HUANG Yunman;HUO Yongli;LI Bolin;SUN Runxue;YIN Lu;CHEN Xian(Hebei Province Chinese Medicine Hospital,Shijiazhuang 050013,Hebei,P.R.China;Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology,Zhangjiakou 076450,Hebei,P.R.China;Hebei Technology Innovation Center of TCM Spleen and Kidney Diseases,Langfang 065399,Hebei,P.R.China)

机构地区：[1]河北省中医院,河北石家庄050013 [2]河北省中西医结合胃肠病研究重点实验室,河北张家口076450 [3]河北省脾肾病证中医治疗技术创新中心,河北廊坊065399

出　　处：《影像科学与光化学》2022年第5期1158-1163,共6页Imaging Science and Photochemistry

基　　金：国家中医临床研究基地建设项目(国中医药办科技函[2018]18号);国家科技部重点研发课题(2018YFC1704100,2018YFC1704102);河北省省级科技计划资助项目(21377724D,21377740D)。

摘　　要：本研究观察益补胃宝汤联合子午流注针法治疗慢性胃炎对患者胃镜下指标的影响。选取136例慢性胃炎患者,采用简单随机方法按1∶1分为对照组(西药常规)和针药联合组(加用益补胃宝汤联合子午流注针法)。比较两组胃蛋白酶原亚群、炎症因子,以及中医症状评分、生活质量评分的差异,观察疗效和安全性。治疗后,针药联合组总有效率明显高于对照组(P<0.05),针药联合组中医症状明显低于对照组,生活质量评分明显高于对照组(P<0.05)。两组治疗后胃蛋白酶原Ⅱ(PGⅡ)、可溶性白细胞介素-2受体(sIL-2R)、趋化因子-1(MCP-1)、肿瘤坏死因子-α(TNF-α)均低于治疗前,胃蛋白酶原Ⅰ(PGⅠ)、PGⅠ/PGⅡ高于治疗前,且针药联合组胃蛋白酶原亚群、炎症因子改善明显优于对照组(P<0.05)。针药联合组胃镜下症状改善状况明显优于对照组(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。益补胃宝汤联合子午流注针法治疗慢性胃炎可调节胃蛋白酶原亚群、炎症因子的表达,改善胃镜下症状表现,且安全性高。This study investigated the effect of Yibuweibao Decoction combined with Ziwu Liuzhu acupuncture on gastroscopic indexes of patients with chronic gastritis. Selected 136 patients with chronic gastritis and divided them into the control group(routine western medicine) and acupuncture drug combination group(plus Yibuweibao Decoction combined with Ziwu Liuzhu acupuncture) according simple random method with principle of 1∶1. Pepsinogen subsets, inflammatory factors were compared between the two groups, and the difference of traditional Chinese medicine(TCM)symptom score, quality of life score, the curative effect and safety were observed.After treatment,the total effective rate in the acupuncture drug combination group was significantly higher than that in the control group(P<0.05).The TCM symptoms in the acupuncture and medicine combination group were significantly lower than those in the control group,and the score of quality of life was significantly higher than those of the control group(P<0.05).Pepsinogen II(PGII),Soluble Interleukin-2Receptor(sIL-2R),Chemokine-1(MCP-1)and Tumor Necrosis Factor-α(TNF-α)after treatment in the two groups were both lower than before treatment,the PepsinogenⅠ(PGⅠ)and PGⅠ/PGⅡwere higher than before treatment,and the improvement of pepsinogen subsets and inflammatory factors in the acupuncture drug combination group were significantly better than those in the control group (P<0.05).The improvement of gastroscopic symptoms in the acupuncture drug combination group was significantly better than that in the control group (P<0.05).There was no significant difference in adverse reactions between the two groups (P>0.05).Yibuweibao decoction combined with Ziwu Liuzhu acupuncture in the treatment of chronic gastritis can regulate the expression of pepsinogen subsets and inflammatory factors,and also can improve the performance of the symptoms under gastroscopy,and has high safety.

关 键 词：益补胃宝汤 子午流注针法 慢性胃炎 胃蛋白酶原亚群 

分 类 号：R259[医药卫生—中西医结合]