Exosomes released by melanocytes modulate fibroblasts to promote keloid formation: a pilot study  

作　　者：Zeren SHEN Jinjin SHAO Jiaqi SUN Jinghong XU 

机构地区：[1]Department of Plastic Surgery the First Affiliated Hospital,Zhejiang University Scchool of Medicine,Hangzhou 310003,China [2]Center of Safety Evaluation and Research,Hangzhou Medical College,Hangzhou 310059,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第8期699-704,共6页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Zhejiang Provincial Natural Science Foundation of China(No.LQ22H150005);the National Natural Science Foundation of China(No.81873937)。

摘　　要：Keloids are a common type of pathological scar as a result of skin healing,which are extremely difficult to prevent and treat without recurrence.The pathological mechanism of keloids is the excessive proliferation of fibroblasts,which synthesize more extracellular matrices(ECMs),including type I/III collagen(COL-1/3),mucopolysaccharides,connective tissue growth factor(CTGF),also known as cellular communication network factor 2(CCN2),and fibronectin(FN)in scar tissue,mostly through the abnormal activation of transforming growth factor-β(TGF-β)/Smads pathway(Finnson et al.,2013;Song et al.,2018).

关 键 词：al. HEALING cytes 

分 类 号：R751[医药卫生—皮肤病学与性病学]