内蒙古自治区托克托县砷暴露地区人群尿中砷、硒、铅、铬元素对血压影响的研究  

Effects of arsenic,selenium,lead and chromium in urine on blood pressure in people from arsenic exposure areas of Togtoh County,Inner Mongolia Autonomous Region

作　　者：许丹妮 刘长海 苏利 赵静 刘赢 赵嵩 夏雅娟 李海玲 Xu Danni;Liu Changhai;Su Li;Zhao Jing;Liu Ying;Zhao Song;Xia Yajuan;Li Hailing(School of Public Health,Inner Mongolia Medical University,Hohhot 010050,China;School of Basic Medicine,Inner Mongolia Medical University,Hohhot 010050,China;Inner Mongolia Autonomous Regional Center for Comprehensive Disease Control,Hohhot 010031,China)

机构地区：[1]内蒙古医科大学公共卫生学院,呼和浩特010050 [2]内蒙古医科大学基础医学院,呼和浩特010050 [3]内蒙古自治区综合疾病预防控制中心,呼和浩特010031

出　　处：《中华地方病学杂志》2022年第7期550-553,共4页Chinese Journal of Endemiology

基　　金：国家自然科学基金(81360414、41230749);内蒙古医科大学科技百万工程项目(YKD2016KJB WD21);内蒙古自治区教育厅(NJZY21614)。

摘　　要：目的:了解内蒙古自治区托克托县砷暴露地区居民高血压发生情况,分析高血压的影响因素。方法:在内蒙古自治区饮水型地方性砷中毒病区托克托县刺猬沟村和与其生活习惯、经济状况相似的非砷中毒病区和林格尔县兰家夭村,选取居住时间≥10年的常住居民作为调查对象,共调查刺猬沟村116名居民(暴露组)和兰家夭村68名居民(对照组)。测量血压,同时检测尿砷、硒、铅、铬含量,采用多因素logistic回归分析高血压的影响因素。结果:暴露组、对照组高血压检出率分别为53.45%(62/116)、70.59%(48/68),组间比较差异有统计学意义(χ^(2)=5.33,P=0.022)。暴露组尿砷、硒、铬含量均高于对照组,尿铅含量低于对照组,差异均有统计学意义(Z=13.04、6.34、11.28、-9.91,P均<0.001)。多因素logistic回归分析结果显示,女性、年龄≥60岁、尿砷含量升高为砷暴露地区高血压的影响因素[比值比(OR)=2.074、2.004、0.424,95%置信区间(CI):1.113~3.866、1.035~3.879、0.219~0.820]。结论:女性、年龄≥60岁、尿砷含量升高为内蒙古自治区托克托县砷暴露地区高血压的影响因素。Objective To learn about the incidence of hypertension in residents of arsenic exposure areas of Togtoh County,Inner Mongolia Autonomous Region,and to analyze the influencing factors of hypertension.Methods In Inner Mongolia Autonomous Region,Ciweigou of Togtoh County,a drinking water-type endemic arsenic poisoning area,and Lanjiayao of Horinger County,a non-arsenic poisoning area with similar living habits and economic conditions,permanent residents who had lived for≥10 years were selected as the survey subjects.Totally 116 residents of Ciweigou(exposure group)and 68 residents of Lanjiayao(control group)were included in the survey.Blood pressure was measured and the contents of arsenic,selenium,lead and chromium in urine were detected,multivariate logistic regression was used to analyze the influencing factors of hypertension.Results The detection rates of hypertension in exposure group and control group were 53.45%(62/116)and 70.59%(48/68),respectively,and the difference between the two groups was statistically significant(χ^(2)=5.33,P=0.022).The contents of arsenic,selenium and chromium in urine of exposure group were higher than those of control group,and the content of lead in urine was lower than that of control group,and the differences were statistically significant(Z=13.04,6.34,11.28,-9.91,P<0.001).The results of multivariate logistic regression analysis showed that female,age≥60 years old and high urinary arsenic content were the influencing factors of hypertension[odds ratio(OR)=2.074,2.004,0.424,95%confidence interval(CI):1.113-3.866,1.035-3.879,0.219-0.820]in arsenic exposure areas.Conclusion Female,age≥60 years old and high urinary arsenic content are the influencing factors of hypertension in arsenic exposure areas of Togtoh County,Inner Mongolia Autonomous Region.

关 键 词：高血压 砷 硒 铅 铬 

分 类 号：R544.1[医药卫生—心血管疾病]