血清内皮抑素、VEGF、EOS、NLR水平与慢性阻塞性肺疾病急性加重的相关性研究  

The Correlation of serum endostatin,VEGF,EOS,NLR levels with acute exacerbation of COPD

作　　者：余玲玲 刘宁 刘冬[2] 许西琳[2] 高岩[2] 辛雯艳 何小双[2] 李皖豫 YU Ling-ling;LIU Ning;LIU Dong(Medicine College of Shihezi University,Shihezi 832000,China;Department of Respiratory Medicine,the First Affiliated Hospital of Shihezi University,Shihezi 832000,China)

机构地区：[1]石河子大学医学院,新疆石河子832000 [2]石河子大学第一附属医院呼吸内科,新疆石河子832000

出　　处：《吉林医学》2022年第9期2355-2359,共5页Jilin Medical Journal

摘　　要：目的:探讨血清内皮抑素(Endostatin)、血管内皮生长因子(VEGF)、中性淋巴细胞比值(NLR)、血嗜酸性粒细胞(EOS)与慢性阻塞性肺疾病急性加重(AECOPD)及慢性阻塞性肺疾病(COPD)的相关性。方法:选取收治的50例AECOPD住院患者,并收集其经过7~14 d治疗后测定其治疗前、后的血清内皮抑素、VEGF、NLR、EOS水平变化并与50例健康对照组进行比较分析。结果:AECOPD患者血清内皮抑素、VEGF、NLR、EOS水平较COPD稳定期及健康对照组均明显升高,差异均有统计学意义(P<0.05)。与入院第1天相比,AECOPD患者入院后第7~14天的血清内皮抑素、VEGF、NLR、EOS水平均明显降低,差异均有统计学意义(P<0.05)。COPD患者急性加重期与稳定期的血清内皮抑素、VEGF、NLR、EOS的灵敏度分别为60%、70%、50%、70%;特异度分别为66%、52%、76%、56%。COPD患者急性加重期与对照组的血清内皮抑素、VEGF、NLR、EOS的灵敏度分别为90%、98%、96%、98%,特异度分别为72%、62%、54%、60%。COPD患者稳定期与对照组的血清内皮抑素、VEGF、NLR、EOS的灵敏度分别为78%、100%、100%、92%,特异度分别为68%、46%、38%、46%。结论:血清内皮抑素、VEGF、NLR、EOS联合检测可作为诊断COPD加重期和COPD稳定期的潜在标志。Objective To investigate the relationship between serum endostatin, vascular endothelial growth factor(VEGF), neutral to lymphocyte ratio(NLR), eosinophil(EOS) and acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and chronic obstructive pulmonary disease(COPD). Method 50 hospitalized patients with AECOPD were collected. After 7~14 days of treatment, the levels of serum endostatin, VEGF, NLR and EOS were measured before and after treatment, and compared with 50 healthy controls.Results The changes of serum endostatin, VEGF, NLR and EOS in patients with acute exacerbation of COPD were slower, and they were significantly higher in stable COPD and healthy control group(P<0.05). Compared with the first day after admission, the levels of serum endostatin, VEGF, NLR and EOS in patients with acute exacerbation of COPD were significantly lower on the 7~14 th day after admission(P<0.05). The sensitivity of serum endostatin, VEGF, NLR and EOS in patients with COPD in acute exacerbation and stable stage were 60%, 70%, 50% and 70%, respectively;The specificity was 66%, 52%, 76% and 56%, respectively. The sensitivity of serum endostatin, VEGF, NLR and EOS in patients with acute exacerbation of COPD and the control group were 90%, 98%, 96% and 98% respectively, and the specificity were 72%, 62%, 54% and 60% respectively. The sensitivity of serum endostatin, VEGF, NLR and EOS in stable COPD patients and control group were 78%, 100%, 100% and 92% respectively, and the specificity were 68%, 46%, 38% and 46% respectively.Conclusion The combined detection of serum endostatin, VEGF, NLR and EOS can be used as a potential marker for the diagnosis of exacerbation and stability of COPD.

关 键 词：慢性阻塞性肺疾病 急性加重 血清内皮抑素 血管内皮生长因子 血嗜酸性粒细胞 中性淋巴细胞比值 诊断 

分 类 号：R563.9[医药卫生—呼吸系统]