叔丁醇钾促进的环化和偶联反应  

Cyclization and Coupling Reactions Promoted by Potassium tert-Butoxide

作　　者：张力之 廖永剑 陈宁 黄磊 周敏 Zhang Lizhi;Liao Yongjian;Chen Ning;Huang Lei;Zhou Min(School of Ethnic Medicine,Yunnan Minzu University,Kunming 650031)

机构地区：[1]云南民族大学民族医药学院,昆明650031

出　　处：《有机化学》2022年第7期1950-1959,共10页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.32060101);云南省优秀青年基金(No.202001AW070002);云南省万人计划(No.YNWR-QNBJ-2019-206);云南省中青年学术带头人后备人才(No.2019HB016)资助项目。

摘　　要：在过去的几十年中,过渡金属催化反应已经发展成为构建各类化学键非常强大的工具.同时,非金属促进的化学键构建反应,由于其避免使用昂贵的金属催化剂和配体,降低反应成本、减少环境污染,符合绿色化学发展理念,越来越受到合成化学家的关注.其中,叔丁醇钾促进的环化和偶联反应得到了迅速的发展.概述了自2000年以来的叔丁醇钾参与的分子内环化和分子间偶联反应,并阐明其可能的反应机理,能帮助化学工作者们更好地了解该领域的发展状况,同时促进该领域的发展.Over the past few decades,transition metal-catalyzed reactions have been developed into a powerful tool for building various chemical bonds.At the same time,non-metal-promoted chemical bond construction reactions have attracted more and more attention of synthetic chemists because of the avoiding of using expensive metal catalysts and ligands,resulting in the reduce of reaction costs and environmental pollution.It conforms to the concept of green chemistry development.Among them,potassium tert-butoxide-promoted cyclization and coupling reactions have been rapidly developed.The intramolecular cyclization and intermolecular coupling reactions involving potassium tert-butoxide since 2000 are summarized,and the possible reaction mechanisms are elucidated,which can help chemists better understand the development of this field and promote the development of this field.

关 键 词：叔丁醇钾 分子内环化 自由基反应 偶联反应 

分 类 号：O621.25[理学—有机化学]