洛森重排反应研究进展  

Recent Advances in Lossen Rearrangement

作　　者：崔银 张国富[1] 丁成荣[1] Cui Yin;Zhang Guofu;Ding Chengrong(College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310014)

机构地区：[1]浙江工业大学化学工程学院,杭州310014

出　　处：《有机化学》2022年第7期2015-2027,共13页Chinese Journal of Organic Chemistry

摘　　要：异氰酸酯是一种重要的有机合成中间体,经霍夫曼重排、柯提斯重排或洛森重排反应等方法制得.与霍夫曼重排和柯提斯重排相比,科学家们对反应条件温和、过程安全和试剂毒害性低的洛森重排反应产生了极大的兴趣,展开了一系列研究和应用.结合洛森重排反应机理,对历年来典型的洛森重排反应的研究成果进行了系统性总结,并对该研究领域的发展前景进行了展望.Isocyanate is an important intermediate in organic synthesis,which could be prepared via the reaction of Hoffman rearrangement,Curtis rearrangement or Lossen rearrangement.Considering avoiding the hazardous and potentially explosive reagents,chemists have focused on Lossen rearrangement and made the progress and applications of this reaction.The development and applications of the typical reactions of Lossen rearrangement based on its mechanism are systematically summarized.The direction of future research is also prospected.

关 键 词：洛森重排 异羟肟酸 异氰酸酯 合成 

分 类 号：O621.259.3[理学—有机化学]