胡蜂毒素Mastoparan的分子改造和定量构效关系研究进展  

Research Progress on Molecular Modifi cation and Qsar of Mastoparan

作　　者：翟培[1] 韩晋辉[1] 吕文平 ZHAI Pei;HAN Jinhui;LYU Wenpin(Guangdong Food and Drug Vocational College,Guangzhou 510520,China;Jiangnan University,Wuxi 210122,China)

机构地区：[1]广东食品药品职业学院,广州510520 [2]江南大学,无锡210122

出　　处：《中国动物传染病学报》2022年第4期229-236,共8页Chinese Journal of Animal Infectious Diseases

基　　金：广东省普通高校重点科研平台和科研项目(2018GKTSCX015);广东食品药品职业学院校级自然科学科研项目(2017ZR012)。

摘　　要：蜂毒用于治疗多种疾病已有几百年的历史,但发现和研究胡蜂毒素Mastoparan的时间还不到40年。早期,胡蜂毒素只是被作为一种生理工具进行研究和使用。近期研究表明,胡蜂毒素在抗多重耐药菌和抗肿瘤方面表现出良好的生物活性,且其结构简单,适合作为QSAR研究的模型肽。本文以近年来国内外胡蜂毒素的相关研究为基础,整理总结胡蜂毒素家族的结构特征及生物学作用,重点对胡蜂毒素分子改造和定量构效关系研究进展和成果进行了综述,期望为抗多重耐药菌及抗肿瘤药物的开发提供参考和思路。Venom of the wasp has been used to treat some diseases for hundreds of years but Mastoparan from wasp venom has been found and studied less than 40 years.Mastoparan was studied and used as a physiological tool in earlier years.Recent studies have shown that Mastoparan has excellent biological activity against multidrug-resistant bacteria and tumors.Besides,Mastoparan with simple structure is suitable for QSAR study as a model peptide.On the basis of the related research,the structural characteristics and biological functions of Mastoparans were summarized and molecular modification and its QSAR were emphatically reviewed in this article to provide references and ideas for the development of new drugs.

关 键 词：胡蜂毒素 生物活性 分子改造 构效关系 

分 类 号：TQ464[化学工程—制药化工]