胡黄连葫芦烷型四环三萜类化合物及其生物活性的研究进展  

Research progress on cucurbitane-type tetracyclic triterpenes in Picrorhizae Rhizoma and their bioactivities

作　　者：吉海杰 郝淑兰 吕林[3] 王淑敏 王晞星 唐旭东[3,4] JI Hai-jie;HAO Shu-lan;LYU Lin;WANG Shu-min;WANG Xi-xing;TANG Xu-dong(Shanxi Province Academy of Traditional Chinese Medicine,Shanxi Traditional Chinese Medical Hospital,Taiyuan 030012,China;Postdoctoral Research Station,China Academy of Chinese Medical Sciences,Beijing 100700,China;Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;China Academy of Chinese Medical Sciences,Beijing 100700,China)

机构地区：[1]山西省中医药研究院&山西省中医院,山西太原030012 [2]中国中医科学院博士后流动站,北京100700 [3]中国中医科学院西苑医院,北京100091 [4]中国中医科学院,北京100700

出　　处：《中草药》2022年第15期4875-4881,共7页Chinese Traditional and Herbal Drugs

基　　金：科技部国家重点研发计划项目(2019YFC1709600);国家自然科学基金面上项目(81873297);国家自然科学基金面上项目(81973672)。

摘　　要：胡黄连Picrorhizae Rhizoma为中医临床清虚热要药,目前一般认为其功效与环烯醚萜类、苯乙醇糖苷类和酚苷类化合物相关,而对于胡黄连所含葫芦烷型四环三萜类化合物及其生物活性关注较少。研究表明含有α,β-不饱和酮结构的葫芦烷型四环三萜属于迈克尔反应受体小分子,具有抗肿瘤等重要药理活性。对胡黄连中的葫芦烷型四环三萜类化合物进行综述,一方面比较了2种基原胡黄连所含葫芦烷型四环三萜类化合物的差异,另一方面对此类化合物的生物活性研究进行总结,为深入探索胡黄连功效的物质基础提供参考。Huhuanglian(Picrorhizae Rhizoma) is used for clearing asthenic fever in traditional Chinese medicine. It has been believed that these effects are related with iridoids, phenylethanol glycosides and phenolic glycosides in Picrorhizae Rhizoma.However, there is little attention on cucurbitane-type tetracyclic triterpenoids and their bioactivities. Studies have shown that cucurbitacins containing α, β-unsaturated ketones belong to Michael reaction receptor molecules, which exert important pharmacological activities such as anti-tumor. Cucurbitane-type tetracyclic triterpenes in Picrorhizae Rhizoma are reviewed in this paper. The distinction in cucurbitacins between Picrorhizae Rhizoma of Picrorhiza kurroa and Picrorhiza scrophulariiflora and bioactivities of cucurbitacins are systematacially summarized, in order to provide reference for further exploring material basis of efficacy of Picrorhizae Rhizoma.

关 键 词：印度胡黄连 西藏胡黄连 葫芦烷型四环三萜 2-O-glucoside-picracin 细胞毒性 免疫调节 

分 类 号：R282.710.5[医药卫生—中药学]