刺五加提取物及其活性成分免疫调节作用的研究进展  

Research progress on immunomodulatory effects of extracts and active ingredients of Acanthopanax senticosus

作　　者：梁子涵 王旖瑶 赖逸翔 张靖怡 宋银宏[1,2,3] LIANG Zi-han;WANG Yi-yao;LAI Yi-xiang;ZHANG Jing-yi;SONG Yin-hong(Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy,China Three Gorges University,Yichang 443002,China;Institute of Infection and Inflammation,China Three Gorges University,Yichang 443002,China;Medical College,China Three Gorges University,Yichang 443002,China)

机构地区：[1]肿瘤微环境与免疫治疗湖北省重点实验室(三峡大学),湖北宜昌443002 [2]三峡大学感染与炎症损伤研究所,湖北宜昌443002 [3]三峡大学医学院,湖北宜昌443002

出　　处：《中草药》2022年第15期4895-4904,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(81671397);湖北省卫健委重点项目(WJ2019H528)。

摘　　要：免疫力下降及免疫失衡是临床多种疾病发生的根源,调节机体免疫力成为许多疾病的有效治疗方法。刺五加Acanthopanax senticosus属于五加科五加属传统药用植物,在临床上常用于病后恢复、改善睡眠和增强机体免疫力等。刺五加提取物一般分为水提取物和醇提取物,其活性成分主要有刺五加多糖、萜类、木脂素类、黄酮类和香豆素类等。刺五加提取物及其活性成分可在增强机体免疫力的同时发挥抗炎作用,体现在刺激细胞因子产生、增强巨噬细胞吞噬功能以及调节多种炎性细胞因子水平等方面。主要对刺五加提取物及其活性成分的免疫作用进行综述,为刺五加临床免疫应用提供一定理论基础。Decreased immune and immune imbalance are the root causes of many clinical diseases, and regulation of body immunity has become an effective treatment for many diseases. Ciwujia(Acanthopanax senticosus) is a traditional medicinal plant belonging to the genus Acanthopanax in Araliaceae, and is commonly used in clinical practice to recover from illness, improve sleep and enhance body’s immunity. The extracts of A. senticosus divided into aqueous and ethanol extracts. Its active ingredients mainly include polysaccharides, terpenoids, lignans, flavonoids and coumarins, etc. The extracts and active ingredients of A. senticosus can exert antiinflammatory effects while enhancing the immunity of the body, which are reflected in stimulating the production of cytokines,enhancing the phagocytic function of macrophages and regulating the levels of various of inflammatory cytokines. A review of the immunological effects of the extracts and active ingredients from A. senticosus was mainly conducted to provide a theoretical basis for the immunological application of A. senticosus in clinic.

关 键 词：刺五加 免疫调节 刺五加多糖 紫丁香苷 金丝桃苷 槲皮素 芦丁 异嗪皮啶 

分 类 号：R285[医药卫生—中药学]