≥40岁良性前列腺增大者前列腺钙化患病率及影响因素分析  

Prevalence of and associated factors for prostate calcification in≥40-year-old males with benign prostatic enlargement

作　　者：张小马[1,2] 肖莉 程宗三 林长明[2] 张力 周骏[1] 郝宗耀[1] 梁朝朝[1] ZHANG Xiao-ma;XIAO Li;CHENG Zong-san;LIN Chang-ming;ZHANG Li;ZHOU Jun;HAO Zong-yao;LIANG Chao-zhao(Department of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230022,China;Department of Urology,Anhui Public Health Clinical Center(formerly the Fourth Affiliated Hospital of Anhui Medical University),Hefei,Anhui 230012,China;Center of Health Management,Anhui Public Health Clinical Center(formerly the Fourth Affiliated Hospital of Anhui Medical University),Hefei,Anhui 230012,China)

机构地区：[1]安徽医科大学第一附属医院泌尿外科,安徽合肥230022 [2]安徽省公共卫生临床中心(原安徽医科大学第四附属医院)泌尿外科,安徽合肥230012 [3]安徽省公共卫生临床中心(原安徽医科大学第四附属医院)健康管理中心,安徽合肥230012

出　　处：《中华男科学杂志》2022年第7期579-584,共6页National Journal of Andrology

基　　金：国家自然科学基金(81870519)。

摘　　要：目的:探讨≥40岁体检良性前列腺增大(BPE)者前列腺钙化(PCal)的患病率及影响因素。方法:回顾性分析671例≥40岁BPE者的体检资料,探讨≥40岁BPE者PCal的患病率,单因素和多因素分析BPE伴PCal的影响因素。结果:BPE伴PCal在1582例≥40岁体检男性中患病率为17.3%,在BPE中患病率为40.8%,随年龄增长而增高(趋势χ^(2)=5.289,P=0.021),PCal在不同年龄段BPE中比例有差异(χ^(2)=9.243,P=0.026)。年龄、身高、估算肾小球滤过率(eGFR)和尿pH在BPE伴PCal和BPE不伴PCal组间有差异(P<0.05);两组间前列腺回声不均患者数有差异(P<0.05)。Logistic分析显示年龄(OR=1.027,95%CI 1.010~1.044)、尿pH(OR=1.446,95%CI 1.148~1.823)和前列腺回声不均(OR=2.150,95%CI 1.108~4.174)是≥40岁BPE者PCal的影响因素。结论:PCal在≥40岁BPE者中患病率较高,随年龄增加而增加。年龄、尿pH、前列腺回声不均是≥40岁体检BPE者PCal的影响因素。Objective:To investigate the prevalence of and risk factors for prostate calcification(PCal)in≥40 years old males with benign prostatic enlargement(BPE)found in health checkup.Methods:We retrospectively analyzed the data on 671≥40-year-old men found with BPE in health checkup and investigated the prevalence of and risk factors for PCal in BPE males aged≥40 years by univariate and multivariate analyses.Results:Among 1582 men aged≥40 years undergoing health checkup,671 were found with BPE and 274(17.3%)with both BPE and PCal.The incidence rate of PCal was 40.8%(274/671)in the BPE patients,which was increased with age(trendχ^(2)=5.289,P=0.021),with statistically significant differences in different age groups(χ^(2)=9.243,P=0.026).Significant differences were also observed in age,height,estimated glomerular filtration rate(eGFR),urine pH level and the number of cases of uneven prostatic echoes between the BPE patients with and those without PCal(P<0.05).Logistic regression analysis showed that age(OR=1.027,95%CI:1.010-1.044),urine pH(OR=1.446,95%CI:1.148-1.823)and uneven prostatic echoes(OR=2.150,95%CI:1.108-4.174)were the associated factors for PCal in BPE patients aged≥40 years.Conclusion:The incidence rate of PCal is high and increased with age in BPE patients aged≥40 years,and age,urine pH and uneven prostatic echoes are associated factors for PCal in this cohort.

关 键 词：前列腺增大 前列腺钙化 健康体检 男性 影响因素 

分 类 号：R697.32[医药卫生—泌尿科学]