6-甲基脲嘧啶及其衍生物的绿色合成  

Green synthesis of 6-methyluracil and its derivatives

作　　者：李闪闪 李丹丹 张鹏[1] 谢智宇 牛亮峰 LI Shan shan;LI Dan dan;ZHANG Peng;XIE Zhi yu;NIU Liang feng(College of Chemical and Materials Engineering,Xuchang University,Henan 461000,P.R.China)

机构地区：[1]许昌学院化工与材料学院,河南许昌461000

出　　处：《内蒙古石油化工》2022年第7期4-7,28,共5页Inner Mongolia Petrochemical Industry

基　　金：许昌学院科研项目(2022YB040)。

摘　　要：以乙酰乙酸乙酯、尿素为原料,对甲苯磺酸为催化剂合成6-甲基脲嘧啶,探讨了不同带水剂和相转移催化剂对产率的影响。较佳反应条件:25ml环己烷做带水剂,1.00g PEG-400做相转移催化剂,反应时间4h,产率为71.4%.在无水碳酸钾存在下,以二甲基甲酰胺和丙酮作溶剂,取代氯化苄、正溴丁烷与6-甲基脲嘧啶反应,合成两种衍生物1,3-二苄基-6-甲基脲嘧啶和1,3-二正丁基-6-甲基脲嘧啶,产率分别为57.5%和51.3%。6-methyluracil was synthesized from methyl acetoacetate and urea by using ptoluenesulfonic acid as catalyst.The effects of phase transfer catalysts,water carrying agents on the yield of 6-meyhyl ura-cil were studied.The optimal reaction conditions:25 mL cyclohexane as water carrying agent,1g polyeth-ylene glycol 400 as phase transfer catalysts,reflow time 4h,the yield of 6-meyhyl uracil was 71.4%.1,3-dibenzyl-6-methyl and 1,3-din-butyl-6-methyl uracil was synthesized from benzyl chloride,n-bromobutane and 6-methyl by using DMF and acetone as solvents under the condiction of anhydrous potassium carbon-ate,The yields of products are respectively 57.5%and 51.3%.

关 键 词：相转移催化剂 带水剂 6-甲基脲嘧啶 衍生物的合成 

分 类 号：O626.414[理学—有机化学]