液碱法合成对甲基苯酚工艺研究  

Synthesis of p-Methyl Phenol by Sodium Hydroxide Solution

作　　者：陈贵军 岳涛 Chen Guijun;Yue Tao(Organic Reaction in Aqueous Engineering Research Center of Shandong Province,Chemical Technology Academy of Shandong Province,Qingdao University of Science and Technology(Jinan),Jinan250014,China)

机构地区：[1]青岛科技大学山东化工研究院山东省水相有机合成及高效清洁分离工程技术研究中心,山东济南250014

出　　处：《山东化工》2022年第16期49-51,共3页Shandong Chemical Industry

基　　金：泰山学者建设工程基金项目(编号ts20130918)。

摘　　要：对甲基苯磺酸钠与液碱在高温下发生碱解反应得到对甲基苯酚(目标化合物),反应条件为:n(对甲苯磺酸钠)∶n(氢氧化钠)=1∶4、液碱浓度为50%,280℃搅拌4 h反应收率95%。反应结束后以二氧化硫酸化分层后精馏得到对甲基苯酚,水溶液减压浓缩得到亚硫酸钠固体。该方法为工业生产提供了参考。P-methyl benzene sulfonic acid sodium and sodium hydroxide solution alkylation react to p-methyl phenol(target compound)under high temperature,reaction conditions:n(p-toluene sulfonic acid sodium)∶n(sodium hydroxide)=1∶4,sodium hydroxide concentration of 50%,280℃stirring 4 h reaction yield of 95%.After the reaction,p-methyl phenol was obtained by acidification stratification of sulfur dioxide and distillation,sodium sulfite solid was obtained by decompression concentration of aqueous solution.This method provides reference for industrial production.

关 键 词：对甲基苯酚 合成 液碱 优化 

分 类 号：O625.312[理学—有机化学]