盐酸丁螺环酮中间体亚胺的生产工艺改进  

Production Process Improvement of Buspirone Hydrochloride Intermediate Imine

作　　者：罗云雷 张慧珍 Luo Yunlei;Zhang Huizhen(PKU HealthCare Co.,Ltd.,Chongqing400714,China;School of Pharmacy,Linyi University,Linyi276000,China)

机构地区：[1]北大医药股份有限公司,重庆400714 [2]临沂大学药学院,山东临沂276000

出　　处：《山东化工》2022年第16期180-182,共3页Shandong Chemical Industry

摘　　要：β,β-四亚甲基戊二酰亚胺(简称:亚胺)是合成丁螺环酮的重要中间体。亚胺的制备方法很多,但都具有高耗能这一特点,不利于工业化生产。通过对工艺的研究,找到了一条收率高、质量稳定、纯度高、条件温和、对设备耐受性强,工业蒸汽即可满足加热要求的适合工业化生产的合成路线。该工艺已完成上百公斤规模的生产试产,具有广阔的工业化生产前景。β,β-Tetramethyleneglutarimide(abbreviation:Imine)is an important intermediate in the synthesis of buspirone.There are many preparation methods of imine,but all of them have the characteristics of high energy consumption,which is not conducive to industrial production.Through the research on the process,a synthetic route suitable for industrial production with high yield,stable quality,high purity,mild conditions,strong equipment tolerance,and industrial steam can meet the heating requirements has been found.The process has completed trial production of hundreds of kilograms,and has broad prospects for industrial production.

关 键 词：β β-四亚甲基戊二酰亚胺 一锅法 工业化 

分 类 号：TQ462[化学工程—制药化工]