Effects of acupuncture on nutritional status in patients in a persistent vegetative state:a prospective randomized controlled study  

针刺对持续植物状态患者营养状况的影响:前瞻性随机对照研究

作　　者：SHI Hanfeng ZHANG Fuqing 石含峰;张馥晴(翻译)(Wuhan Hospital of Traditional Chinese and Western Medicine,Hubei 430000,China;不详)

机构地区：[1]Wuhan Hospital of Traditional Chinese and Western Medicine,Hubei 430000,China [2]不详

出　　处：《Journal of Acupuncture and Tuina Science》2022年第4期281-287,共7页针灸推拿医学（英文版）

摘　　要：Objective To explore the effects of acupuncture on nutritional status in patients in a persistent vegetative state.Methods A prospective randomized controlled trial was designed.A total of 66 patients in a persistent vegetative state were randomized into a control group and an observation group,with 33 cases in each group.The control group was given conventional treatment plus enteral nutrition support.The observation group was treated with additional Tiao Shen Jian Pi acupuncture therapy(acupuncture for spirit-regulating and spleen-invigorating)based on the same interventions in the control group.Both groups were treated for 8 weeks.The levels of total protein(TP),prealbumin(PA),albumin(Alb),and hemoglobin(Hb)were measured before and after treatment.The upper arm circumference and skinfold thickness of triceps brachii were measured.And the intestinal flora and fecal short-chain fatty acids contents were determined.Results After treatment,the levels of TP,PA,Alb,and Hb in the control group were decreased(P<0.05),while in the observation group,compared with those before treatment,the levels of TP,PA,Alb,and Hb had no statistical differences(P>0.05),and the levels were all higher than those in the control group(P<0.05).The upper arm circumference and skinfold thickness of triceps brachii in both groups decreased(P<0.05),and the values of these two items in the observation group were higher than those in the control group(P<0.05).In the control group,the contents of Bifidobacterium and Lactobacillus in feces decreased(P<0.05),and the content of Enterococcus increased(P<0.05).In the observation group,the contents of Bifidobacterium and Lactobacillus in feces increased(P<0.05),and the content of Enterococcus decreased(P<0.05).The differences between the two groups were statistically significant(P<0.05).In the control group,the total content of fecal short-chain fatty acids and the contents of acetic acid and butyric acid in feces decreased(P<0.05).In the observation group,the total content of fecal short-chain fatty a目的探讨针刺对持续植物状态患者营养状况的影响。方法采用前瞻性随机对照试验设计。将66例持续植物状态患者随机分为对照组和观察组,每组33例。对照组予常规治疗配合肠内营养支持,观察组在对照组干预基础上加用调神健脾针刺,治疗8周。治疗前后测定总蛋白(TP)、前白蛋白(PA)、白蛋白(Alb)及血红蛋白(Hb)水平,测量上臂围及肱三头肌皮褶厚度,测定肠道菌群及粪便短链脂肪酸含量。结果治疗后,对照组TP、PA、Alb、Hb水平均降低(P<0.05),观察组TP、PA、Alb、Hb水平与治疗前差异均无统计学意义(P>0.05),且均高于对照组(P<0.05)。两组患者上臂围、肱三头肌皮褶厚度均减小(P<0.05),观察组两项指标数值均大于对照组(P<0.05)。对照组粪便双歧杆菌、乳杆菌含量降低(P<0.05),肠球菌含量升高(P<0.05);观察组双歧杆菌、乳杆菌含量升高(P<0.05),肠球菌含量降低(P<0.05),与对照组差异均有统计学意义(P<0.05)。对照组粪便短链脂肪酸总含量及乙酸、丁酸含量降低(P<0.05),观察组粪便短链脂肪酸总含量及乙酸、丁酸含量均升高(P<0.05),且高于对照组(P<0.05)。结论针刺可改善持续植物状态患者营养相关血液指标,延缓上臂围、肱三头肌皮褶厚度的减小,可能与其调节肠道菌群及粪便短链脂肪酸含量有关。

关 键 词：Acupuncture Therapy Persistent Vegetative State Nutritional Status HEMOGLOBINS Gastrointestinal Microbiome Fatty Acids Volatile 

分 类 号：R246.6[医药卫生—针灸推拿学]