尿源性脓毒症早期诊断指标的研究进展  

Research progress on early diagnositic biomarkers of urinary sepsis

作　　者：丁西杰 胡卫国[2] Ding Xijie;Hu Weiguo(Department of Urology,Affiliated Hospital of Qinghai University,Graduate School of Qinghai University,Xining 810000,China;Department of Urology,Tsinghua Changgung Hospital,School of Clinical Medicine,Tsinghua University,Beijing 102218,China)

机构地区：[1]青海大学附属医院泌尿外科,青海大学研究生院,西宁810000 [2]清华大学附属北京清华长庚医院泌尿外科,清华大学临床医学院,北京102218

出　　处：《中华泌尿外科杂志》2022年第8期632-636,共5页Chinese Journal of Urology

摘　　要：Sepsis-3定义在脓毒症诊断中的价值已被广泛接受和应用。白细胞(WBC)、血小板计数、C反应蛋白(CRP)、降钙素原(PCT)和白蛋白等指标在尿源性脓毒症早期预警和诊断中应用最为广泛和方便,PCT的特异性和敏感性相对更高,WBC急剧下降对脓毒性休克具有很强的预警性,CRP的特异性相对低。IL-6、CD64、Presepsin、miRNA、PTX-3等是较新的更有价值的指标,具有更高的敏感性和特异性,但对检测技术要求较高,需要统一和规范的检测标准。多个生物标志物的组合以及与临床评分系统结合较单个生物标志物更具有临床应用价值。The accuracy of the Sepsis-3 definition in the diagnosis of sepsis has been widely accepted and applied.Indicators such as Procalcitonin(PCT),white blood cell(WBC),C-reactive protein(CRP),platelets(PLT)and albumin are the most extensively and conveniently applied in early alert and diagnosis of urinary sepsis.PCT has a higher specificity and sensitivity compared to other biomarkers,and a sharp drop in WBC is a strong warning for septic shock.However,CRP has a relatively low specificity.IL-6,CD64,Presepsin,miRNA,and PTX-3,among others,are more valuable emerging indicators with higher sensitivity and specificity.However,uniform and standardized technology is necessary for a high quality testing.The combination of multiple biomarkers with a clinical scoring system is more useful than individual biomarkers clinically.This article mainly reviewed the progress of research on indicators related to early alert and diagnosis of urinary sepsis during recent years.

关 键 词：脓毒症 尿源性脓毒症 诊断生物标志物 多指标预测模型 

分 类 号：R459.7[医药卫生—急诊医学]