热固化聚富马酸丙二醇酯/丙烯酸羟乙酯材料的制备与性能  

Preparation and properties of thermally-cured poly(propylene fumarate)/hydroxyethyl acrylate system materials

作　　者：王亮 张格青[1] 辛怡 范李庆 贺辛亥 张萌 WANG Liang;ZHANG Geqing;XIN Yi;FAN Liqing;HE Xinhai;ZHANG Meng(School of Materials Science and Engineering,Xi'an Polytechnic University,Xi'an 710048,Shaanxi,China;Xi'an Key Laboratory of Textile Composites,Xi'an Polytechnic University,Xi'an 710048,Shaanxi,China)

机构地区：[1]西安工程大学材料工程学院,陕西西安710048 [2]西安工程大学西安市纺织复合材料重点实验室,陕西西安710048

出　　处：《精细化工》2022年第8期1626-1632,共7页Fine Chemicals

基　　金：国家自然科学基金(51273159);西安市碑林区科技计划项目(GX2141);陕西省医用金属材料重点实验室开放课题基金(SXBMM-201903);西安工程大学博士科研启动基金(BS201861)。

摘　　要：以富马酸二乙酯和1,2-丙二醇为原料,通过两步反应成功合成了聚富马酸丙二醇酯(PPF),以PPF和丙烯酸羟乙酯以不同质量比热固化构筑体系材料。利用FTIR、^(1)HNMR对PPF进行了表征,通过TG-DSC、全自动视频接触角测试仪、拉伸试验机测试了体系材料的热稳定性、润湿性能、力学强度,评价了体系材料的体外细胞毒性及降解性能。结果表明,体系材料具有较好的热稳定性、亲水性及力学强度,其水接触角为(53.28°±2.36°)~(76.17°±0.81°),拉伸剪切强度、拉伸粘接强度、最大抗压强度、三点弯曲强度分别为(1.33±0.08)~(1.63±0.54)MPa、(1.86±0.07)~(3.18±0.29)MPa、(60.47±3.47)~(88.15±7.09)MPa、(18.77±1.12)~(20.63±1.48)MPa。体外降解实验结果表明,随着浸泡时间的延长,体系溶液pH呈下降趋势,pH变化值为0.093~0.628。当PPF和丙烯酸羟乙酯质量比为3∶1时,试样3的失重率和吸水率最高,分别可达11.20%和38.27%,降解速率较为缓慢。此外,体系材料对MC3T3-E1小鼠颅顶前骨细胞的毒性轻微。Poly(propylene fumarate)(PPF)was successfully synthesized from diethyl fumarate and 1,2-propanediol via two-step reaction and characterized by FTIR and^(1)HNMR.And then a series of thermally cured system materials were obtained by mixing PPF and hydroxyethyl acrylate in different mass ratios.The thermal stability,wetting properties and mechanical strength of system materials were measured by TG-DSC,automatic video contact angle and tensile machine,followed by in vitro cytotoxicity and degradation evaluation.The results showed that the system materials exhibited good thermal stability,hydrophilicity with water contact angles ranging from(53.28°±2.36°)to(76.17°±0.81°),and mechanical strength,with tensile shear strength,tensile bonding strength,maximum compressive strength and three-point bending strength of(1.33±0.08)~(1.63±0.54)MPa,(1.86±0.07)~(3.18±0.29)MPa,(60.47±3.47)~(88.15±7.09)MPa and(18.77±1.12)~(20.63±1.48)MPa,respectively.In vitro degradation analysis indicated the system pH displayed a decrease trend with soaking time.The pH variation value was 0.093~0.628.Meanwhile,system material with a mass ratio of PPF to hydroxyethyl acrylate of 3∶1showed maximum mass loss rate and water absorption rate,which were 11.20%and 38.27%,respectively,indicating a relatively slow degradation rate.Moreover,in vitro cytotoxicity analysis on murine cell line MC3T3-E1 demonstrated that the system materials displayed mild cell proliferation inhibition.

关 键 词：聚富马酸丙二醇酯 热固化 表征 力学强度 降解性能 功能材料 

分 类 号：R318.08[医药卫生—生物医学工程] TB332[医药卫生—基础医学]