海洛因损伤成瘾者大脑半球间镜像同伦连接  

The heroin injury voxel-mirrored homotopic connectivity between cerebral hemispheres of addicts

作　　者：陈佳杰 蔡关科 王澍 黄鹏 李依峣 李玮 王玮 李强 CHEN Jiajie;CAI Guanke;WANG Shu;HUANG Peng;LI Yiyao;LI Wei;WANG Wei;LI Qiang(Department of Radiology,the Second Affiliated Hospital of Air Force Military Medical University,Xi'an 710038,China;Department of Medical Imaging,Shaanci Provincial Hospital of Chinese Medicine,Xi'an 710003,China;MR Product Division,Canon Medical Systems(China),Xi'an 710016,China;Team 6,Group 2,Cadet Team,School of Basic Medicine,the Air Force Military Medical University,Xi'an 710032,China)

机构地区：[1]空军军医大学第二附属医院放射科,陕西西安710038 [2]陕西省中医医院医学影像科,陕西西安710003 [3]佳能医疗系统(中国)有限公司MR产品事业部,陕西西安710016 [4]空军军医大学基础医学院学员队二大队六队,陕西西安710032

出　　处：《实用放射学杂志》2022年第7期1057-1060,共4页Journal of Practical Radiology

基　　金：空军军医大学第二附属医院培育资助项目(“尖子人才”2019)。

摘　　要：目的探讨海洛因成瘾者(HD)大脑双侧半球间同伦连接的损伤及其与吸食海洛因时间的相关性。方法招募32例HD(HD组)和40名健康对照(HC组)进行人口学与静息态功能MR数据采集。采用体素镜像同伦连接(VMHC)方法比较组间脑半球连接差异,分析差异脑区与吸食海洛因时间的相关性。结果与HC组相比,HD组双侧额上回、梭状回、舌回、海马旁回、尾状核、丘脑的VMHC值显著降低(P<0.05,FDR校正),HD大脑梭状回VMHC值与吸食海洛因时间呈负相关性(r=-0.47,P=0.007)。结论HD抑制控制、奖赏、视觉相关脑区VMHC显著减弱,这可能是HD脑功能损伤的神经生物学标志之一。Objective To investigate the damage of bilateral hemispheric homotopic connections in heroin dependent(HD)and the correlation between the strength of the connections and the duration of heroin use.Methods Thirty-two HD(HD group)and 40 healthy controls(HC group)were recruited for demographic and resting-state functional MR data collection.The voxel-mirrored homotopic connectivity(VMHC)method was used to compare the differences of hemispheric connections between the two groups.The correlation between different brain regions and the duration of heroin use was analyzed.Results Compared with the HC group,the VMHC values of the bilateral superior frontal gyrus,fusiform gyrus,lingual gyrus,parahippocampal gyrus,caudate nucleus and thalamus were significantly lower in the HD group(P<0.05,FDR corrected).The fusiform gyrus VMHC values of HD was negatively correlated with the duration of heroin use(r=-0.47,P=0.007).Conclusion HD have significantly reduced VMHC in brain areas related to inhibition,control,reward,and vision.These may be one of the neurobiological markers of impaired brain function in HD.

关 键 词：海洛因成瘾 体素镜像同伦连接 梭状回 

分 类 号：R996[医药卫生—毒理学] R742[医药卫生—药学]