水凝胶在青光眼缓控释递药中的研究进展  

Research Progress on Hydrogel-based Sustained and Controlled Drug Delivery for Glaucoma

作　　者：姚晓长[1] 陈锋[2] YAO Xiaochang;CHEN Feng(Xiangya Hospital,Central South University,Office of Clinical Drug Trial Administration,Changsha 410008,China;Xiangya Hospital,Central South University,Department of Pharmacy,Changsha 410008,China)

机构地区：[1]中南大学湘雅医院临床药物试验管理办公室,长沙410008 [2]中南大学湘雅医院药学部,长沙410008

出　　处：《中国现代应用药学》2022年第16期2165-2172,共8页Chinese Journal of Modern Applied Pharmacy

摘　　要：青光眼严重影响正常视觉功能,但目前药物治疗效率低下。眼部缓控释制剂可以延长药物作用时间,减少给药次数,提高患者顺应性。水凝胶是一类在眼科中用途极其广泛的材料,预制凝胶和原位凝胶在眼科药物的缓控释递送中显示出极大潜力。以接触镜为代表的预制凝胶则可提供持续的药物释放和眼前滞留。原位凝胶兼具溶液剂给药方便和凝胶剂延缓释药的优势。本文就近几年不同给药途径中将水凝胶应用于抗青光眼药物缓控释研究中的进展进行归纳和总结,并讨论水凝胶在青光眼的治疗中存在的挑战,希望能为其临床使用提供参考。Glaucoma affects normal visual function seriously,but the efficiency of drug treatment is low.Sustained and controlled-release ophthalmic preparations can prolong the duration time of the drug,reduce the times of administrations,and improve patient compliance.Hydrogels are a class of materials that are extremely versatile in ophthalmology.Preformed gels and in situ gels show great potential for the sustained delivery of ophthalmic drugs.Preformed gels represented by contact lenses provide sustained drug release and prolonged drug duration time while in situ gels have the advantage of both ease of administration and delayed release of drugs.The research progress of sustained and controlled release gels in the delivery of anti-glaucoma drugs in recent years are summarized,the current challenges during research and application process are discussed,expected to provide the reference for its clinical application.

关 键 词：水凝胶 青光眼 缓控释递药 接触镜 原位凝胶 

分 类 号：R944.9[医药卫生—药剂学]