生殖道解脲支原体感染患者PCT、CRP水平变化及相关危险因素分析  

Procalcitonin and C-reactive protein levels in patients with genital ureaplasma urealyticum infection and analysis of related risk factors

作　　者：江舟 李晶晶[1] Jiang Zhou;Li Jingjing(Department of Gynecology,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China)

机构地区：[1]温州医科大学附属第一医院妇科,温州325000

出　　处：《中国基层医药》2022年第8期1136-1140,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨已婚女性生殖道解脲支原体(Uu)感染患者的降钙素原(PCT)、C反应蛋白(CRP)水平变化及感染的危险因素。方法选择2019年1-12月温州医科大学附属第一医院收治的已婚女性生殖道Uu感染患者116例作为观察组,另选择同期在该院进行体检的健康已婚妇女50例作为对照组。检测、比较两组血清PCT、CRP水平,对比两组的调查问卷结果,对影响生殖道Uu感染发生的危险因素进行单因素分析及logistic多因素回归分析。结果观察组的PCT、CRP水平分别为(3.71±0.64)μg/L、(34.26±4.23)mg/L,均明显高于对照组[(0.49±0.16)μg/L、(4.84±0.75)mg/L](t=35.05、48.76,均P < 0.001)。观察组中每次使用避孕套、无流产史、性伴侣为1人、初次性生活年龄≥ 20岁、性交频次≤ 3次/周、无不洁性接触史和知晓Uu知识感染的患者比例分别为54.55%、24.24%、65.15%、54.55%、42.42%、69.70%、34.85%,均明显低于对照组的80.00%、48.00%、88.00%、76.00%、66.00%、94.00%、60.00%(χ^(2)=9.79、9.33、8.81、6.89、7.89、11.56、9.32,P=0.002、0.009、0.003、0.008、0.005、0.001、0.002)。多因素分析结果显示,流产次数、性伴侣人数、初次性生活年龄 < 20岁、性交频次和不洁性接触史均为影响Uu感染发生的独立危险因素(OR=2.12、3.58、2.34、2.84、4.24),高频次使用避孕套和知晓Uu感染知识为保护性因素(OR=4.03、3.03)。结论已婚女性生殖道Uu感染患者的血清PCT、CRP水平异常升高,可作为早期诊断的敏感性指标。性交频次、性伴侣人数、流产次数偏多、性生活过早及不洁性接触史是导致其发生的危险因素。Objective To investigate the changes in procalcitonin(PCT)and C-reactive protein(CRP)levels in married women with genital ureaplasma urealyticum infection and analyze the risk factors of genital ureaplasma urealyticum infection.Methods A total of 116 married women with genital ureaplasma urealyticum infection who received treatment in the First Affiliated Hospital of Wenzhou Medical University from January 2019 to December 2019 were included in the observation group.An additional 50 healthy married women who concurrently received physical examination in the same hospital were included in the control group.Serum levels of PCT and CRP were compared between the two groups.Questionnaire outcomes and the risk factors for genital ureaplasma urealyticum infection were subjected to univariate analysis and logistic regression analysis.Results Serum levels of PCT and CRP in the observation group were(3.71±0.64)μg/L and(34.26±4.23)mg/L,respectively,which were significantly higher than those in the control group[(0.49±0.16)μg/L,(4.84±0.75)mg/L,t=35.05,48.76,both P<0.001].In the observation group,the proportions of women who used condom each time,who had no abortion,who had one sexual partner,who had first sexual intercourse at the age of≥20 years,who had sexual intercourse≤3 times/week,who had no history of unclean sexual contact,and who knew knowledge of genital ureaplasma urealyticum infection were 54.55%,24.24%,65.15%,54.55%,42.42%,69.70%,34.85%,respectively,which were significantly lower than those in the control group[80.00%,48.00%,88.00%,76.00%,66.00%,94.00%,60.00%,χ^(2)=9.79,9.33,8.81,6.89,7.89,11.56,9.32,P=0.002,0.009,0.003,0.008,0.005,0.001,0.002).Multivariate analysis showed that abortion frequency,number of sexual partners,age at first sexual intercourse<20 years,frequency of sexual intercourse and history of unclean sexual contact were independent risk factors for genital ureaplasma urealyticum infection(OR=2.12,3.58,2.34,2.84,4.24).Frequent condom use and knowledge of genital ureaplasma urealyticum in

关 键 词：解脲素支原体 生殖道感染 危险因素 降钙素原 C反应蛋白质 性生活 流产 避孕套 

分 类 号：R711.3[医药卫生—妇产科学]