系统性自身免疫性疾病患者aCL和aβ2GPI与缺血性脑卒中的相关性研究  

Correlations of anti-cardiolipin antibody and anti-β2 glycoprotein I antibody with ischemic stroke in patients with systemic autoimmune diseases

作　　者：艾娇 刘静 王瑞[3] 袁国华[1] Ai Jiao;Liu Jing;Wang Rui;Yuan Guohua(Department of Rheumatology and Immunology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan Province,China;Institute of Rheumatology and Immunology,North Sichuan Medical College,Nanchong 637000,Sichuan Province,China;Department of Rheumatology and Immunology,People's Hospital of Leshan,Leshan 614000,Sichuan Province,China)

机构地区：[1]川北医学院附属医院风湿免疫科,南充637000 [2]川北医学院风湿免疫研究所,南充637000 [3]乐山市人民医院风湿免疫科,乐山614000

出　　处：《中国基层医药》2022年第8期1151-1155,共5页Chinese Journal of Primary Medicine and Pharmacy

基　　金：川北医学院科研发展计划项目(CBY20-QA-Y17);川北医学院附属医院科研课题项目(2021JC020)。

摘　　要：目的探讨系统性自身免疫性疾病(SADs)患者抗心磷脂抗体(aCL)和抗β2糖蛋白Ⅰ抗体(aβ2GPI)与缺血性脑卒中(IS)的相关性。方法选取川北医学院附属医院2019年1-12月诊治的SADs患者104例,依据是否合并IS分为两组:合并IS的SADs患者42例为病例组(IS组),未合并IS的SADs患者62例为对照组(non-IS组)。定性比较IS组与non-IS组抗磷脂抗体(aPLs)阳性率,定量比较两组aCL、aβ2GPI表达水平的差异,并采用logistic回归分析评估SADs患者罹患IS的危险因素。结果 IS组aPLs阳性率为61.9%(26/42),明显高于non-IS组的40.3%(25/62),差异有统计学意义(χ^(2)=4.66,P=0.031)。IS组aCL-IgM、aβ2GPI-IgM分别为(22.82±27.27)RU/mL、(18.70±23.95)RU/mL,均明显高于non-IS组的(13.34±8.43)RU/mL、(7.61±5.80)RU/mL,差异均有统计学意义(t=-2.18、-2.76,P=0.034、0.009)。logistic回归分析结果显示,aPLs是IS发生的独立危险因素(P=0.037)。结论 aCL和aβ2GPI与SADs患者IS发生有密切联系,是SADs患者发生IS的独立危险因素。Objective To correlate anti-cardiolipin antibody(aCL)and anti-β2 glycoprotein I antibody(aβ2GPI)with ischemic stroke(IS)in patients with systemic autoimmune diseases(SADs).Methods A total of 104 patients with SADs who received treatment in the Affiliated Hospital of North Sichuan Medical College during January to December 2019 were included in this study.They were divided into two groups whether they had IS(IS group,n=42)or not(non-IS group,n=62).aPL positive rate was qualitatively compared between the IS and non-IS groups.aCL and aβ2GPI expression levels were quantitatively compared between the IS and non-IS groups.Logistic regression analysis was performed to evaluate the risk factors for IS in patients with SADs.Results aPL positive rate in the IS group was significantly higher than that in the non-IS group[61.9%(26/42)vs.40.3%(25/62),χ^(2)=4.66,P=0.031].The aCL-IgM and aβ2GPI-IgM levels in the IS group were(22.82±27.27)RU/mL and(18.70±23.95)RU/mL,respectively,which were significantly higher than those in the non-IS group[(13.34±8.43)RU/mL,(7.61±5.80)RU/mL,t=-2.18,-2.76,P=0.034,0.009].Logistic regression analysis showed that aPL is an independent risk factor for IS(P=0.037).Conclusion aCL and aβ2GPI are closely related to the occurrence of IS and are the independent risk factors for IS in patients with SADs.

关 键 词：自身免疫疾病 卒中 抗体 抗磷脂 抗心磷脂抗体 糖蛋白类 β2糖蛋白Ⅰ 红斑狼疮 系统性 关节炎 类风湿 

分 类 号：R593.2[医药卫生—内科学] R743.3[医药卫生—临床医学]