柔性纤维生物电子复合材料与器件  

Flexible Fiber Bioelectronic Composite Materials and Devices

作　　者：郭悦 王佳佳 王立媛 孙雪梅[1] 彭慧胜[1] Yue Guo;Jia-jia Wang;Li-yuan Wang;Xue-mei Sun;Hui-sheng Peng(State Key Laboratory of Molecular Engineering of Polymers,Department of Macromolecular Science,Laboratory of Advanced Materials,Fudan University,Shanghai 200438)

机构地区：[1]聚合物分子工程国家重点实验室,复旦大学高分子科学系先进材料实验室,上海200438

出　　处：《高分子学报》2022年第7期707-721,共15页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号52122310,22075050)资助项目。

摘　　要：可穿戴和可植入的纤维生物电子器件可以实现对人体生理体征的实时监测和精准调控,在健康监测和疾病诊疗等领域发挥了革新作用.然而,传统的纤维生物电子器件柔性不足而与生物软组织的力学性能不匹配,难以形成稳定的器件/组织界面,最终无法实现长期稳定工作.本文重点介绍了近年来课题组针对上述问题在柔性纤维生物电子复合材料与器件方面的研究进展.首先制备了具有杂化结构和芯鞘结构的柔性高分子复合纤维电极,并面向柔性生物电子器件要求,对纤维材料的电学和力学性能及生物安全性进行表征.进一步,基于所制备的复合纤维电极,发展出一系列可穿戴和可植入的纤维生物电子器件,具有传感、能源、调控等功能,并通过建立稳定的器件/组织界面,实现了在体长期工作,在生物医学研究和智慧医疗等领域展现出良好的应用前景.最后,展望了柔性纤维生物电子领域的未来发展方向.Wearable and implantable fiber bioelectronics can continuously collect physiological information and accurately modulate physiological environment, which have revolutionized the conventional way of health monitoring, disease diagnosis and treatment. However, most of the fiber bioelectronics reported so far have insufficient flexibility. They do not match the soft tissues mechanically and cannot form stable device/tissue interface, limiting their long-term use. In this feature article, we mainly introduced our recent progress on flexible fiber bioelectronic composite materials and devices, aiming to solve the problem above. We first introduced the fabrication of flexible polymer composite fibers with hybrid or core-sheath structure, which possess good electrical and mechanical properties as well as biocompatibility. Based on the high-performance flexible polymer composite fibers, a series of fiber bioelectronics with functions of biosensing, energy-harvesting and storage, and electrochemical modulating were constructed for wearable and implantable applications, which showed promising prospects in healthcare and medicine. Finally, we discussed the future development direction of flexible fiber bioelectronics.

关 键 词：高分子复合纤维 碳纳米管 柔性 纤维生物电子器件 

分 类 号：TB332[一般工业技术—材料科学与工程] TN03[电子电信—物理电子学]