芳基锡烷的合成研究进展  

Recent Advances in the Synthesis of Arylstannanes

作　　者：岳广禄 魏婧瑶 邱頔 莫凡洋[2] Yue Guanglu;Wei Jingyao;Qiu Di;Mo Fanyang(Tianjin Key Laboratory of Structure and Performance for Functional Molecules,College of Chemistry,Tianjin Normal University,Tianjin 300387,China;School of Materials Science and Engineering,Peking University,Beijing 100871,China)

机构地区：[1]天津师范大学化学学院天津市功能分子结构与性能重点实验室,天津300387 [2]北京大学材料科学与工程学院,北京100871

出　　处：《化学学报》2022年第7期956-969,共14页Acta Chimica Sinica

基　　金：天津市教委高等学校科技发展基金计划项目(No.2020KJ007)资助。

摘　　要：芳基锡烷化合物是参与构筑功能分子中芳基碳碳键和碳杂原子键的一类重要合成中间体.其在药物化学、材料科学以及有机合成中都具有重要应用,因此发展其高效新颖的合成方法具有重要的意义.根据反应机理的类型,综述了近些年来合成芳基锡烷的方法,包括(1)芳香亲核试剂的锡化反应;(2)芳香亲电试剂的锡化反应;(3)过渡金属催化的锡化偶联反应;(4)芳基自由基中间体介导的锡化反应;(5)炔烃的环化和串联的锡化反应.最后,进一步分析了未来合成芳基锡烷的研究趋势.Arylstannanes are highly valuable synthetic intermediates in constructing aryl carbon-carbon bonds and carbon-heteroatom bonds in functional molecules.These compounds have demonstrated great applications in medicinal chemistry,materials science and organic synthesis.Due to the synthetic value,development of efficient and novel methods to synthesize arylstannanes is of significant importance.According to the type of reaction mechanism,this content will illustrate the methods for synthesizing arylstannanes in recent years including(1)stannylation of aromatic nucleophiles;(2)stannylation of aromatic electrophiles;(3)transition-metal-catalyzed stannylation coupling reactions;(4)stannylation reactions mediated by aryl radical intermediates;(5)cyclization of alkynes and tandem stannylation.Finally,we further provide a perspective on the development direction of the synthesis of arylstannanes.

关 键 词：芳基锡烷 Stille交叉偶联 锡化反应 芳基自由基 

分 类 号：O627.42[理学—有机化学]