胶体粒子的机械性能调控及其在药物递送中的应用  

Tuning the Mechanical Properties of Colloid Particles for Drug Delivery

作　　者：高至亮 李梦琦 郝京诚[1] 崔基炜 Gao Zhiliang;Li Mengqi;Hao Jingcheng;Cui Jiwei(Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education,Shandong University,Jinan 250100)

机构地区：[1]山东大学胶体与界面化学教育部重点实验室,济南250100

出　　处：《化学学报》2022年第7期1010-1020,共11页Acta Chimica Sinica

基　　金：国家自然科学基金(Nos.21872085,22102088);山东省自然科学基金(No.ZR202102240400)资助。

摘　　要：胶体粒子是肿瘤治疗中最常用的载体,尽管在过去的研究中不同的胶体粒子已经被广泛报道,但如何进一步提高胶体粒子的药物递送效率仍然存在着一些挑战.大量的研究表明胶体粒子的尺寸、形状、结构和表面化学等物理化学性质在药物递送过程中具有重要的作用,但胶体粒子的机械性能对药物递送过程的影响研究和综述相对较少.本综述从不同机械性能胶体粒子的制备与表征出发,概述了胶体粒子的机械性能对血液循环、肿瘤富集、渗透以及细胞内化过程的影响,并对该领域存在的问题以及发展的趋势进行了展望.该综述有助于帮助科学工作者更好地理解胶体粒子的机械性能对药物递送的影响规律,从而优化胶体粒子的设计并提高纳米药物的递送效率和生物利用率.Colloidal particles are the most common carriers of anticancer drugs.Although various colloidal particles as carriers have been reported,it is still challenging to enhance the drug delivery efficacy.It has been proved that physicochemical properties(e.g.,size,shape,structure,and surface chemistry)of colloidal particles play an important role in drug delivery processes,while the influence of the mechanical property of colloidal particles on the drug delivery process is rarely reported and reviewed.In this review,we summarize the preparation and characterization of colloidal particles with different mechanical properties.The influence of the mechanical properties of colloidal particles on blood circulation,tumor accumulation and penetration as well as cell internalization are also highlighted.Furthermore,the challenges and future directions in this field are discussed,which is helpful to understand the influence of mechanical property on the design of colloidal particles as carriers to improve the drug delivery efficacy and bioavailability of nanomedicines.

关 键 词：胶体粒子 机械性能 纳米-生物相互作用 药物递送 纳米载体 

分 类 号：R943[医药卫生—药剂学]