Functional mutations of SARS-CoV-2:implications to viral transmission,pathogenicity and immune escape  

作　　者：Shengyuan Dang Lili Ren Jianwei Wang 

机构地区：[1]National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory,Institute of Pathogen Biology,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China [2]Key Laboratory of Respiratory Disease Pathogenomics,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China

出　　处：《Chinese Medical Journal》2022年第10期1213-1222,共10页中华医学杂志（英文版）

基　　金：This review was supported by the Medical and Health Science and Technology Innovation Project of Chinese Academy of Medical Sciences(No. 2021-I2M-1-040)。

摘　　要：The pandemic of coronavirus disease 2019 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to major public health challenges globally. The increasing viral lineages identified indicate that the SARS-CoV-2 genome is evolving at a rapid rate. Viral genomic mutations may cause antigenic drift or shift, which are important ways by which SARS-CoV-2 escapes the human immune system and changes its transmissibility and virulence. Herein, we summarize the functional mutations in SARS-CoV-2 genomes to characterize its adaptive evolution to inform the development of vaccination, treatment as well as control and intervention measures.

关 键 词：Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Mutation Variants of concern Variants of interest Adaptive evolution 

分 类 号：R392[医药卫生—免疫学]