NCPAP及NIPPV与NHFOV三种无创通气策略治疗早产新生儿呼吸窘迫综合征的比较  

Comparison of NCPAP,NIPPV and NHFOV noninvasive ventilation strategies in treatment of premature neonatal respiratory distress syndrome

作　　者：邱晓蕾 赵志娟[1] QIU Xiao-lei;ZHAO Zhi-juan(Department of Neonatology,Anyang Maternal and Child Health Hospital,Anyang,Henan 455000,China)

机构地区：[1]安阳市妇幼保健院新生儿科,河南安阳455000

出　　处：《医药论坛杂志》2022年第13期24-26,30,共4页Journal of Medical Forum

基　　金：2017年度河南省医学科技攻关计划项目(201702324)。

摘　　要：目的比较经鼻持续正压通气(NCPAP)、经鼻间歇正压通气(NIPPV)及无创高频震荡通气(NHFOV)三种无创通气方式作为初始通气方式在早产儿呼吸窘迫综合征中的有效性及安全性。方法选取2019年2月—2021年2月安阳市妇幼保健院接受并进行治疗的120例呼吸窘迫综合征早产新生儿作为研究对象,采用回顾性分析法根据患儿具体情况将其进行匹配,从而分出采用不同无创通气策略的3组患儿,其中NCPAP组患儿43例,NIPPV组患儿29例,NHFOV组患儿48例。统计并对比3组患儿的治疗状况、通气失败插管率、住院天数以及死亡率。结果NHFOV组患儿的同期失败插管率和死亡率均少于其他两组患儿,NIPPV组患儿的相关指标则更低于NCPAP组患儿(P<0.05);3组患儿的住院天数并无明显差异,不具有统计学意义(P>0.05)。结论相较于NCPAP治疗策略而言,采用NIPPV和NHFOV治疗策略能够更有效的保护发生呼吸窘迫综合征患儿的生命健康状况,在这两种方案中又以NHFOV的治疗效率最高,在实际情况以及患儿身体状况符合的情况下,应当优先选用NHFOV进行治疗,具有较高的临床推广价值。Objective To compare the efficacy and safety of NCPAP,NIPPV and NHFOV as initial ventilation methods in the treatment of respiratory distress syndrome in premature infants.Methods Selected 120 cases of preterm neonatal respiratory distress syndrome in our hospital from February 2019 to February 2021 as the research object,using retrospective analysis method to match it,on the basis of the condition of the children to distinguish different noninvasive ventilation strategy of three groups,including NCPAP group of 43 cases of children,children with NIPPV group 29 cases,There were 48 patients in NHFOV group.The treatment status,ventilation failure intubation rate,hospitalization days and mortality of the three groups were analyzed and compared.Results The rate of failed intubation and mortality in the NHFOV group were lower than those in the other two groups,and the related indicators in the NIPPV group were even lower than those in the NCPAP group(P<0.05).There was no significant difference in the days of hospitalization among the three groups(P>0.05).Conclusion Compared with NCPAP treatment strategy,NIPPV and NHFOV treatment strategy can more effectively protect the life and health status of children with respiratory distress syndrome.Among these two strategies,NHFOV has the highest treatment efficiency,and NHFOV should be preferred for treatment when the actual situation and physical condition of children are consistent.It has a high value of clinical promotion.

关 键 词：NCPAP NIPPV NHFOV 早产新生儿 呼吸窘迫综合征 

分 类 号：R722[医药卫生—儿科]