基于纳米载药技术的丹参难溶性成分在抗肿瘤治疗中的研究进展  

Research progress in the insoluble components of Salvia miltiorrhiza based on nano drug loading technology in antitumor therapy

作　　者：张文君[1,2] 石雅琪 王立 杨硕[1] 吕春艳 ZHANG Wen-jun;SHI Ya-qi;WANG Li;YANG Shuo;LV Chun-yan(School of Pharmacy,Harbin University of Commerce,Heilongjiang Harbin 150076,China;Heilongjiang Key Laboratory for tumor prevention and antitumor drugs,Heilongjiang Harbin 150076,China;Department of Pharmacy,Xiamen Medical College,Fujian Xiamen 361023,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]黑龙江省肿瘤预防与抗肿瘤药物研究重点实验室,黑龙江哈尔滨150076 [3]厦门医学院药学系,福建厦门361023

出　　处：《中国医院药学杂志》2022年第15期1619-1624,共6页Chinese Journal of Hospital Pharmacy

基　　金：黑龙江省博士后科研启动基金(编号:LBH-Q20104);2019年度哈尔滨商业大学“青年创新人才”支持计划(编号:2019CX12)。

摘　　要：丹参难溶性成分因能对抗多种恶性肿瘤而成为很好的抗肿瘤候选药物,但因其水溶性差、半衰期短、生物利用度低,极大限制了其临床应用。随着纳米技术的持续发展,基于纳米粒、脂质体、聚合物胶束等中药纳米给药系统能够很好地克服这些不足并被开发应用于临床。本文对近年报道的丹参难溶性成分纳米给药系统在抗肿瘤治疗中的研究进展进行综述,以期为今后进一步开发丹参难溶性成分的纳米给药系统提供理论依据。The insoluble components of Salvia miltiorrhiza have become good antitumor candidates because they can resist a variety of malignant tumors, but their clinical application is greatly limited because of their poor water solubility, short half-life and low bioavailability. With the continuous development of nanotechnology, traditional Chinese medicine nano delivery systems based on nanoparticles, liposomes and polymer micelles can overcome these shortcomings and be developed and applied in clinic. This paper reviewed the research progress in nano drug delivery system of the insoluble components of Salvia miltiorrhiza in antitumor therapy reported in recent years, so as to provide theoretical basis for the further development of nano drug delivery system of the insoluble components of Salvia miltiorrhiza in the future.

关 键 词：丹参难溶性成分 抗肿瘤 纳米给药系统 

分 类 号：R944.9[医药卫生—药剂学]