基于光纤光栅传感器的体外血管模型应力测量  

Circumferential stress measurement of blood vessels model in vitro based on fiber Bragg grating sensor

作　　者：张妍 张帆[1,2] 赵冠棋[3] 初大平 ZHANG Yan;ZHANG Fan;ZHAO Guanqi;CHU Daping(Key Laboratory for Optoelectronic Measurement Technology and Instrument(Ministry of Education),Beijing Information Science and Technology University,Beijing 100192,China;Overseas Expertise Introduction Center for Discipline Innovation,Beijing Information Science and Technology University,Beijing 100192,China;Emergency Critical Care Center,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China)

机构地区：[1]北京信息科技大学光电测试技术及仪器教育部重点实验室,北京100192 [2]北京信息科技大学先进光电子器件与系统创新引智基地,北京100192 [3]首都医科大学附属北京安贞医院急诊危重症中心,北京100029

出　　处：《应用光学》2022年第5期1007-1014,共8页Journal of Applied Optics

基　　金：国家自然科学基金(61875237,61605011);科研重点培育项目(5211910920);北京市教育委员会科技计划项目(KM201711232004)。

摘　　要：血管中的血液流动会对血管壁产生周向应力,周向应力与血管的结构及功能变化密切相关,测量体外血管模型的周向应力是生物力学研究中较重要的问题。提出了利用光纤光栅测量血管周向应力的方法,基于微流控技术利用钢针模具建立了集成光纤光栅的三维圆形血管模型,通过仿真研究了不同流动速度与应力的关系。仿真结果得到流速在8 mm/s~75 mm/s范围内,应力随速度的改变呈线性变化。利用光纤光栅传感器测量了流体流动时产生的周向应力,根据实验得到了光栅波长改变量与速度的关系,流速范围在8 mm/s~75 mm/s之间变化时,速度引起波长的变化为0.173 nm。结合仿真实验得到了应力与光栅波长改变量的关系,为血液流动时产生周向应力的体外测量提供了新思路。The circumferential stress caused by blood flow in blood vessels is closely related to the structural and functional changes of blood vessels. Measuring the circumferential stress of blood vessel models in vitro is an important issue in biomechanics research. A method for measuring the circumferential stress of blood vessels by using fiber gratings was proposed, and a three-dimensional circular blood vessel model integrating fiber gratings was established by using steel needle mold based on microfluidic technology. The relationship between different flow velocities and stress was studied through simulation. The simulation results show that the stress changes linearly with the flow velocity in the range of 8 mm/s~75 mm/s. The circumferential stress generated by fluid flow was measured by fiber Bragg grating sensor. According to the experiment, the relationship between wavelength change of grating and velocity was obtained. When the flow velocity range varies from 8 mm/s to 75 mm/s, the wavelength change caused by velocity is 0.173 nm. The relationship between stress and wavelength change of grating was obtained by simulation experiment. A microfluidic blood vessel model with fiber Bragg grating sensor was proposed and implemented, which provides a new idea for measuring circumferential stress in vitro when blood flows.

关 键 词：体外血管模型 光纤光栅 周向应力 微流控技术 

分 类 号：TN29[电子电信—物理电子学] TP212.3[自动化与计算机技术—检测技术与自动化装置]