泮托拉唑治疗消化性溃疡合并上消化道出血患者的临床效果  

Effect of Pantoprazole on Peptic Ulcer with Upper Gastrointestinal Hemorrhage

作　　者：刘卫 LIU Wei(Laohu Central Health Center,Dongping 271511,China)

机构地区：[1]山东省东平县老湖镇中心卫生院,山东东平271511

出　　处：《中国医药指南》2022年第26期69-71,共3页Guide of China Medicine

摘　　要：目的观察泮托拉唑治疗消化性溃疡合并上消化道出血患者的临床效果,为临床用药提供依据。方法选择2019年3月至2020年3月本院收治的消化性溃疡合并上消化道出血患者75例,采用随机数表法将所有消化性溃疡合并上消化道出血的患者随机分成两组,泮托拉唑组40例,对照组35例,所有患者均接受基础治疗,泮托拉唑组患者应用泮托拉唑治疗,对照组患者应用巴曲亭进行止血治疗,记录两组患者停止出血时间和不良事件发生情况,同时对药物效果进行评价。结果泮托拉唑组患者的总有效率为97.50%,对照组的总有效率为77.1%,差异有统计学意义(χ^(2)=5.530,P=0.020);泮托拉唑组患者平均出血停止时间为(1.30±0.40)d,显著短于对照组的(3.70±0.70)d,差异有统计学意义(t=18.500,P<0.05);泮托拉唑组患者平均住院时间为(7.10±0.60)d,显著短于对照组的(9.20±1.10)d,差异有统计学意义(t=10.440,P<0.05)。在试验期间,所有患者未发生任何死亡、危及生命等不良事件。结论泮托拉唑治疗消化性溃疡合并上消化道出血患者的临床效果良好,可有效止血。Objective To observe the clinical effect of pantoprazole on peptic ulcer with upper gastrointestinal hemorrhage,and to provide basis for clinical medication.Methods A total of 75 patients with peptic ulcer combined with upper gastrointestinal bleeding who were admitted to our hospital from March 2019 to March 2020 were selected.All patients with peptic ulcer complicated with upper gastrointestinal hemorrhage were randomly divided into two groups:pantoprazole group 40 cases,control group 35 cases,all patients received basic treatment,the patients in the pantoprazole group were treated with pantoprazole,the patients in the control group were treated with bacitretin for hemostasis,and the time of stopping bleeding and the occurrence of adverse events were recorded,the drug effect was evaluated.Results.Results The total effective rate of pantoprazole group was 97.50%,and the total effective rate of control group was 77.1%,the difference was statistically significant(χ^(2)=5.530,P=0.020).The average bleeding stop time in the pantoprazole group was(1.30±0.40)d,which was significantly shorter than that in the control group(3.70±0.70)d,and the difference was statistically significant(t=18.500,P<0.05).The average hospital stay in the pantoprazole group was(7.10±0.60)d,which was significantly shorter than that in the control group(9.20±1.10)d,and the difference was statistically significant(t=10.440,P<0.05).During the trial,all patients did not experience any adverse events such as death and life-threatening.Conclusion Pantoprazole has a good clinical effect in the treatment of peptic ulcer patients with upper gastrointestinal bleeding,and can effectively stop bleeding.

关 键 词：消化道溃疡 上消化道出血 质子泵抑制剂 泮托拉唑 止血效果 

分 类 号：R683[医药卫生—骨科学]