TGF-β1/Smads信号通路与气道重塑的相关性和针刺干预研究进展  

Research progress in the correlation of TGF-β1/Smads signaling pathway with airway remodeling by acupuncture intervention

作　　者：张倩[1] 乔赟[1] 时宜蓉 ZHANG Qian;QIAO Yun;SHI Yirong(College of Acupuncture-Moxibustion and Tuina,Guangxi University of Chinese Medicine,Nanning,Guangxi 530200,China)

机构地区：[1]广西中医药大学针灸推拿学院,广西南宁530200

出　　处：《湖南中医药大学学报》2022年第9期1570-1573,共4页Journal of Hunan University of Chinese Medicine

基　　金：广西自然科学基金面上项目(2017GXNSFAA198201,2020GXNSFAA297021)。

摘　　要：气道重塑是哮喘致死的关键因素,一旦形成,难以逆转。基于转化生长因子-β1(transforming growth factor-β1,TGF-β1)/Smads信号通路与哮喘气道重塑的密切关系,既往研究已初步表明针刺通过调控TGF-β1/Smads信号通路实现抑制气道重塑的发展进程。本文从指标检测、研究方案、取穴标准、针刺时机4个方面对针刺调控TGF-β1/Smads信号通路干预气道重塑的实验研究进行分析并得出解决方案,为今后研究工作提供参考。Airway remodeling is a key factor in death from asthma,and once formed,it is difficult to reverse.Based on the close relationship between the transforming growth factor-β1(TGF-β1)/Smads signaling pathway and airway remodeling in asthma,the previous studies have preliminarily shown that acupuncture suppresses the developmental progression of airway remodeling by regulating the TGF-β1/Smads signaling pathway.In this paper,the experimental research on the intervention of acupuncture on TGF-β1/Smads signaling pathway in airway remodeling was analyzed and solutions were produced from four aspects:indicator detection,research scheme,acupoint selection standard and acupuncture timing,aiming to provide reference for the future research.

关 键 词：气道重塑 哮喘 TGF-β1/Smads信号通路 针刺 进展研究 

分 类 号：R245.3[医药卫生—针灸推拿学]