环状RNA调控缺血再灌注后心肌细胞损伤方式及中医药干预研究进展  

Research progress in circRNA regulation of cardiomyocyte injury after ischemia-reperfusion and intervention of traditional Chinese medicine

作　　者：张仪 刘洋[1] 南俞彤 李昊楠 苏友贤 陈聪[1] ZHANG Yi;LIU Yang;NAN Yutong;LI Haonan;SU Youxian;CHEN Cong(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2022年第9期1574-1580,共7页Journal of Hunan University of Chinese Medicine

基　　金：湖南省卫生健康委员会科研计划项目(202202084742);湖南省教育厅科学研究项目(20C1392);宁夏自治区重点研发项目(2020BFH02003);湖南中医药大学科研基金重点项目(2021XJJJ003);湖南省大学生研究性学习和创新性实验计划项目(20191667)。

摘　　要：再灌注损伤是缺血性心脏病恢复供血后,最常见的病理表现之一,多种细胞损伤方式参与其中。通过研究环状RNA分子在心血管疾病中的相关文献,以环状RNA调控心肌缺血再灌注损伤后自噬、凋亡、焦亡等不同细胞损伤方式为切入点,就环状RNA在心肌缺血再灌注中的作用及中医药干预作一综述,探讨中医药与环状RNA在缺血再灌注后心肌细胞中的关系,并明确环状RNA这类生物分子作为心肌缺血再灌注损伤临床治疗潜在靶点的可能性,并为后续研究提供新思路。Reperfusion injury is one of the most common pathologic manifestations after the blood supply is restored from ischemic heart disease,and a variety of cell damage modes are involved.By studying the related literature of circRNA molecules in cardiovascular diseases,we took the regulation of circRNA in different cell injury modes such as autophagy,apoptosis,and pyroptosis after myocardial ischemia-reperfusion injury as the entry point,and analyzed the role of circRNA in myocardial ischemia-reperfusion and the intervention of traditional Chinese medicine.We discussed the relationship between traditional Chinese medicine and circRNA in myocardial cells after ischemia-reperfusion,and clarified the possibility of biological molecules such as circRNA as potential targets for clinical treatment of myocardial ischemia-reperfusion injury,aiming to provide new ideas for subsequent research.

关 键 词：心肌缺血再灌注损伤 环状RNA 中医药 

分 类 号：R256.2[医药卫生—中医内科学]