沙眼衣原体异常网状体在体外不同诱导条件下的变化特点及可能机制  

Various features of Chlamydia trachomatis aberrant reticulate body under different induction conditions in vitro and the possible mechanisms

作　　者：王梅 尤聪[2] 王江懿 赵乐然[3] 邵丽丽[3] 刘全忠[3] Wang Mei;You Cong;Wang Jiangyi;Zhao Leran;Shao Lili;Liu Quanzhong(Department of Dermatology and Venereology,School of Medicine,Nankai University,Tianjing First Central Hospital,Tianjin 300192,China;Sub-center of National Clinical Research Center for Dermatologic and Immunologic Diseases,Department of Dermatology and Venereology,First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;Department of Dermatology and Venereology,Tianjin Medical University General Hospital,Tianjin 300052,China)

机构地区：[1]天津市第一中心医院,南开大学医学院皮肤性病科,天津300192 [2]国家皮肤与免疫性疾病临床研究中心分中心建设单位,赣南医学院第一附属医院皮肤性病科,赣州341000 [3]天津医科大学总医院皮肤性病科,天津300052

出　　处：《中华微生物学和免疫学杂志》2022年第8期659-665,共7页Chinese Journal of Microbiology and Immunology

基　　金：江西省教育厅科学技术研究项目(GJJ201519)。

摘　　要：沙眼衣原体泌尿生殖道持续感染可能导致女性盆腔炎、异位妊娠和输卵管性不孕,男性尿道炎、附睾炎等诸多并发症,是国内外疾病控制的热点和难点。近年来,国内外研究表明沙眼衣原体异常网状体可能是导致持续感染的重要原因之一。本综述通过不同体外条件下诱导的沙眼衣原体异常网状体,分析其基因组学及蛋白质组学特征,以期确立异常网状体在治疗抵抗中发挥的重要作用。对异常网状体相关因素的识别,为亚临床难治性慢性感染的检测提供新的诊断目标,是找到治疗沙眼衣原体感染并发症的适当方法的先决条件,对于识别后基因组时代的新靶点至关重要。Persistent Chlamydia trachomatis urogenital tract infection may lead to pelvic inflammatory disease,ectopic pregnancy and tubal infertility in women,and urethritis,epididymitis and other complications in men,which is a hotspot and chanllenge in disease control at home and abroad.In recent years,many researches have shown that Chlamydia trachomatis aberrant reticulate body may be one of the major causes of persistent infection.This review summarized the genomic and proteomic characteristics of Chlamydia trachomatis aberrant reticulate body induced under various conditions in vitro,aiming to elucidating its role in antimicrobial resistance.The identification of persistent infection-related factors,providing new diagnostic targets for the detection of subclinically refractory long-term infections,is a prerequisite for finding appropriate methods to diagnose and treat the complications of Chlamydia trachomatis infection and is crucial for identifying new targets in the post-genomic era.

关 键 词：沙眼衣原体 异常网状体 持续感染 基因组学 蛋白质组学 

分 类 号：R374.1[医药卫生—病原生物学]