骨碎补活性成分治疗骨骼系统疾病研究进展  

Research Progress of Gusuibu(Drynariae Rhizoma)and Its Active Ingredients in the Treatment of Skeletal System Diseases

作　　者：邓强[1] 乔小万 李中锋[1] 彭冉东 张凯东 罗林钊 杨海云 杨军[2] DENG Qiang;QIAO Xiaowan;LI Zhongfeng;PENG Randong;ZHANG Kaidong;LUO Linzhao;YANG Haiyun;YANG Jun(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu,China;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu,China)

机构地区：[1]甘肃省中医院,甘肃兰州730050 [2]甘肃中医药大学,甘肃兰州730000

出　　处：《辽宁中医药大学学报》2022年第7期1-5,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：甘肃省科技计划项目(重点研发计划)(20YF3FA014);兰州市科技局社会发展项目(2017-RC-44);白求恩·脊柱病理性骨折椎体强化治疗专项基金项目(BK-JP2018004)。

摘　　要：骨碎补作为经典骨伤科要药,具有补肾强骨、续伤止痛之功效。在治疗肾虚腰痛、耳鸣耳聋、牙齿松动、跌扑闪挫、筋骨折伤等方面具有独到的临床疗效。现代药理研究表明骨碎补含有的黄酮类、三萜类、苯丙素类等活性成分具有促进骨损伤修复、延缓椎间盘退变、抗骨质疏松、治疗股骨头坏死等多种防治骨骼系统疾病的药理作用,其机制与调控骨代谢信号通路、细胞因子等高度相关。该文通过查阅近年来关于骨碎补活性成分防治骨质疏松、骨关节炎等骨骼系统疾病的实验进展、临床研究等文献报道,对骨碎补活性成分及其防治骨骼系统疾病的研究进展进行综述,以期对骨碎补后续的实验研究、相关药物研发、临床应用提供相关参考。Gusuibu(Drynariae Rhizoma),as a classic orthopedic medicine,has the effects of invigorating the kidney and strengthening the bones,continuing injury and relieving pain.It has unique clinical effects in the treatment of kidney deficiency,low back pain,tinnitus and deafness,loose teeth,flickering and frustration,and tendon fracture injuries.Modern pharmacological studies have shown that Gusuibu(Drynariae Rhizoma)contains flavonoids,triterpenes,phenylpropanoids and other active ingredients that can promote bone damage repair,delay intervertebral disc degeneration,resist osteoporosis,treat femoral head necrosis,and other skeletal system diseases.Its pharmacological effects are highly related to the regulation of bone metabolism signaling pathways and cytokines.In this paper,by reviewing recent literature reports on the experimental progress and clinical research of Gusuibu(Drynariae Rhizoma)active ingredients in the prevention and treatment of osteoporosis,osteoarthritis and other skeletal system diseases,the research on the active ingredients of Gusuibu(Drynariae Rhizoma)and its effects in the prevention and treatment of skeletal system diseases.The progress is reviewed in order to provide relevant reference for the follow-up experimental research,related drug development,and clinical application of Gusuibu(Drynariae Rhizoma).

关 键 词：骨碎补 活性成分 骨骼系统疾病 进展 综述 

分 类 号：R282.6[医药卫生—中药学] R681[医药卫生—中医学]