外敷骨痹散治疗膝骨性关节炎临床研究  

Clinical observation on external application of Gubi Powder in treatment of knee osteoarthritis

作　　者：李东东 陈光友 丁辉 李晓明 朱凯 刘艳 姜铧财 彭道琥 代浩平 LI Dong-dong;CHEN Guang-you;DING Hui;LI Xiao-ming;ZHU Kai;LIU Yan;JIANG Hua-cai;PENG Dao-hu;DAI Hao-ping(Department of Orthopedics and Traumatology,The Affiliated Hospital of Southwest Medical University,Luzhou 646000;Chongqing Tongnan District Hospital of TCM,Chongqing 402660;Southwest Medical University School of Clinical Medicine,Luzhou 646000;Drug and Functional Food Discovery Research Center,Southwest Medical University,Luzhou 646000)

机构地区：[1]西南医科大学附属中医医院骨伤科,四川泸州646000 [2]重庆潼南区中医医院,重庆402660 [3]西南医科大学临床医学院,四川泸州646000 [4]西南医科大学药物与功能性食品研究中心,四川泸州646000

出　　处：《湖北中医药大学学报》2022年第4期82-84,共3页Journal of Hubei University of Chinese Medicine

基　　金：四川省科技厅重点项目(项目编号:18ZDYF3541);西南医科大学大学生创新创业计划项目(项目编号:2020263)。

摘　　要：目的观察骨痹散治疗膝骨性关节炎的临床疗效。方法将我院82例患者随机分为治疗组与对照组各41例,治疗组采用我院骨痹散外用治疗,对照组采用洛索洛芬钠凝胶膏外用治疗。观察两组治疗前后临床疗效、视觉模拟疼痛评分(VAS)、WOMAC骨关节炎指数评分(WOMAC)及检测肿瘤坏死因子-α(TNF-α)和白细胞介素-1β(IL-1β)细胞因子的变化。结果治疗后,治疗组临床疗效显著高于对照组(P<0.05);治疗组血清细胞因子TNF-α、IL-β表达水平低于对照组(P<0.05);治疗组VAS疼痛评分及WOMAC功能评分均低于对照组(P<0.05)。结论骨痹散可明显改善膝骨性关节炎患者症状,降低患者炎性因子水平,对膝骨性关节炎治疗有良好的临床疗效。Objective To observe the clinical efficacy of Gubi Powder on knee osteoarthritis(KOA).Methods Eightytwo patients with KOA were randomly divided into treatment group and control group,41 cases each.Treatment group received Gubi Powder,and control group received loxoprofen sodium gel ointment.The changs of Visual Analogue Scale(VAS)score,WOMAC Osteoarthritis Index(WOMAC)score,tumor necrosis factor-α(TNF-α)and interluekin(IL)-1β before and after treatment were compared between the two groups.Results After treatment,the clinical efficacy in treatment group was significantly better than in control group(P<0.05);serum TNF-αand IL-1β levels were significantly lower in treatment group than in control group(P<0.05);VAS score andWOMAC score were significantly lower in treatment group than in control group(P<0.05).Conclusion The clinical effect of Gubi Powder for treating knee osteoarthritis is better than loxoprofen gel ointment.

关 键 词：膝骨性关节炎 骨痹散 细胞因子 

分 类 号：R271.4[医药卫生—中医妇科学]