人免疫球蛋白结合利巴韦林注射液治疗小儿传染性单核细胞增多症的效果及对心肌酶谱的影响  

Effect of human immunoglobulin combined with ribavirin injection in the treatment of infectious mononucleosis in children and its influence on myocardial zymogram

作　　者：胡玉玲 王栋梅[2] 马文玲 高永伟 HU Yuling;WANG Dongmei;MA Wenling;GAO Yongwei(Pediatrics Department,Yan'an City Hospital of TCM,Yan'an 716000;Pediatrics Department,Yan'an People's Hospital,Yan'an 716000;Pediatrics Department,the People's Hospital of Zhidan County,Yan'an 717500;Pediatrics Department,Yan'an University Affiliated Hospital,Yan'an 716000,China)

机构地区：[1]延安市中医医院儿科,陕西延安716000 [2]延安市人民医院儿科,陕西延安716000 [3]延安市志丹县人民医院儿科,陕西延安717500 [4]延安大学附属医院儿科,陕西延安716000

出　　处：《临床医学研究与实践》2022年第27期107-110,共4页Clinical Research and Practice

摘　　要：目的探讨人免疫球蛋白结合利巴韦林注射液治疗小儿传染性单核细胞增多症的效果及对心肌酶谱的影响。方法选取2019年11月至2020年11月于本院诊治为传染性单核细胞增多症的60例患儿作为研究对象,以随机数字表法将其分为对照组和观察组,各30例。对照组在常规对症治疗基础上给予利巴韦林注射液治疗,观察组在常规对症治疗基础上给予人免疫球蛋白结合利巴韦林注射液治疗。比较两组治疗前、后的炎症因子、心肌酶谱指标、免疫功能指标水平及临床疗效、不良反应发生情况。结果治疗后,两组患儿的肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)和白细胞介素-6(IL-6)、肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)水平均明显降低,且观察组低于对照组(P<0.05)。治疗后,两组的白细胞分化抗原3阳性(CD3^(+))、白细胞分化抗原4阳性(CD4^(+))及白细胞分化抗原4阳性/白细胞分化抗原8阳性(CD4^(+)/CD8^(+))均明显升高,白细胞分化抗原8阳性(CD8^(+))均明显降低,且观察组优于对照组(P<0.05)。观察组的治疗总有效率显著高于对照组(P<0.05);两组的不良反应总发生率无明显差异(P>0.05)。结论人免疫球蛋白结合利巴韦林注射液治疗小儿传染性单核细胞增多症的临床效果显著,可明显降低患儿的炎症因子及心肌酶谱指标水平,改善免疫功能指标,且不增加不良反应发生率,值得临床推广。Objective To investigate the effect of human immunoglobulin combined with ribavirin injection in the treatment of infectious mononucleosis in children and its influence on myocardial zymogram.Methods A total of 60 children with infectious mononucleosis diagnosed and treated in our hospital from November 2019 to November 2020 were selected as the study objects.The children were divided into control group and observation group by random number table method,with 30 cases in each group.The control group was treated with ribavirin injection on the basis of routine symptomatic treatment,and the observation group was treated with human immunoglobulin combined with ribavirin injection on the basis of routine symptomatic treatment.The levels of inflammatory factors,myocardial zymogram indexes,immune function indexes before and after treatment,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-6(IL-6),creatine kinase isoenzyme(CK-MB)and creatine kinase(CK)in the two groups significantly decreased,and those in the observation group were lower than the control group(P<0.05).After treatment,the cluster of differentiation 3 positive(CD3^(+)),cluster of differentiation 4 positive(CD4^(+))and cluster of differentiation 4 positive/cluster of differentiation 8 positive(CD4^(+)/CD8^(+))in the two groups significantly increased,and the cluster of differentiation 8 positive(CD8^(+))significantly decreased,and those in the observation group were better than the control group(P<0.05).The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05);there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion The human immunoglobulin combined with ribavirin injection in the treatment of infectious mononucleosis in children has a significant clinical effect.It can significantly reduce th

关 键 词：传染性单核细胞增多症 人免疫球蛋白 利巴韦林注射液 心肌酶谱 

分 类 号：R725.1[医药卫生—儿科] R512.7[医药卫生—临床医学]