早产儿肠道菌群与大脑发育的关系  

Relationship between intestinal flora and brain development in premature infants

作　　者：孙瑾 于盼盼 宋施仪[1] 张云峰[1] 田昕[1] Sun Jin;Yu Panpan;Song Shiyi;Zhang Yunfeng;Tian Xin(Department of Pediatrics,the Second Hospital of Jilin University,Changchun 130000,China)

机构地区：[1]吉林大学第二医院儿科诊疗中心,长春130000

出　　处：《中华实用儿科临床杂志》2022年第17期1358-1360,共3页Chinese Journal of Applied Clinical Pediatrics

摘　　要：各种原因引起的早产使早产儿肠道菌群发育不良。在生命早期,肠道微生物群和神经系统有平行的发育窗口。早产儿是一类特殊的人群,早期的微生物定植和微生物群的优化会影响大脑发育并改善神经系统发育的结果。本文就早产儿肠道菌群的因素、早产儿肠道菌群失调对神经系统发育的影响以及早期添加益生菌对早产儿发育的影响进行综述。了解微生物群的早期优化在早产儿大脑发育中的作用,对于开发特定的针对肠道微生物群的疗法,保护婴儿免受因早产而产生的一系列神经发育障碍至关重要。Preterm delivery caused by various reasons leads to intestinal flora dysplasia in premature infants.In the early stages of life,there is a parallel development window between the intestinal microflora and the nervous system.Premature infants represent a unique population,whose brain development can be influenced by early microbial colonization.Microbiota optimization can improve the development of the nervous system.In this article,factors affecting the intestinal flora of premature infants,the effects of intestinal flora imbalance on the nervous system development,and the impact of early addition of probiotics on the development of premature infants were reviewed.Understanding the role of early optimization of the microbiota in the brain development of premature infants is essential for developing specific treatments for intestinal microbiota imbalance and protecting premature infants from a series of neurodevelopmental disorders caused by preterm delivery.

关 键 词：婴儿 早产 神经发育 肠道菌群 

分 类 号：R722.6[医药卫生—儿科]