妊娠糖尿病患者再次妊娠发生糖代谢异常的相关因素  

Related Factors of Abnormal Glucose Metabolism in Re-pregnant Diabetes Patients

作　　者：刘华琪 刘芳 LIU Huaqi;LIU Fang(Department of Obstetrics and Gynecology,Zhecheng Hospital of Traditional Chinese Medicine,Shangqiu 476200,China)

机构地区：[1]柘城中医院妇产科,河南商丘476200

出　　处：《河南医学研究》2022年第18期3357-3360,共4页Henan Medical Research

摘　　要：目的探讨妊娠糖尿病(GDM)患者再次妊娠糖代谢异常发生情况,并分析其影响因素。方法选择2018年12月至2021年12月于柘城中医院接受定期产检的105例初次妊娠时发生GDM的患者作为研究对象。所有患者接受血糖检查,根据糖代谢异常发生情况,分为发生组与未发生组。比较两组基线资料,分析GDM患者再次妊娠糖代谢异常的影响因素。结果105例GDM患者中49例发生糖代谢异常,56例未发生糖代谢异常;发生组前次妊娠24~28周时口服葡萄糖耐量试验(OGTT)2 h血糖高于未发生组,再次妊娠前体质量指数(BMI)≥24 kg·m^(-2)、有DM家族史、合并甲状腺功能减退患者占比高于未发生组(P<0.05);logistic回归分析结果显示,前次妊娠24~28周时75 g OGTT服糖后2 h血糖、再次妊娠前BMI≥24 kg·m^(-2)、有DM家族史、合并甲状腺功能减退是GDM患者再次妊娠糖代谢异常的危险因素(OR>1,P<0.05)。结论前次妊娠24~28周时OGTT 2 h血糖、再次妊娠前BMI≥24 kg·m^(-2)、有DM家族史、合并甲状腺功能减退是GDM患者再次妊娠糖代谢异常的危险因素。Objective To investigate the occurrence of abnormal glucose metabolism in re-pregnant patients with gestational diabetes mellitus(GDM),and to analyze its influencing factors.Methods A total of 105 patients with GDM during first pregnancy who underwent regular prenatal examination in Zhecheng Hospital of Traditional Chinese Medicine from December 2018 to December 2021 were selected as the research subjects.All patients received blood glucose examination and were divided into occurrence group and non occurrence group according to the occurrence of abnormal glucose metabolism.The baseline data of the two groups were compared,and the influencing factors of abnormal glucose metabolism in GDM patients with re-pregnant were analyzed.Results Among 105 patients with GDM,49 had abnormal glucose metabolism,and 56 had no abnormal glucose metabolism.The blood glucose in the occurrence group was higher than that in the non occurrence group at 2 h of oral glucose tolerance test(OGTT)at 24-28 weeks of previous pregnancy,the proportions of patients with body mass index(BMI)≥24 kg·m^(-2),family history of DM and hypothyroidism before re-pregnant were higher than those in the non occurrence group(P<0.05).Logistic regression analysis showed that the risk factors of abnormal glucose metabolism in GDM patients with re-pregnant were blood glucose 2 h after glucose administration of 75 g OGTT at 24-28 weeks of the previous pregnancy,BMI≥24 kg·m^(-2) before re-pregnant,family history of DM,and hypothyroidism(OR>1,P<0.05).Conclusion Blood glucose 2 h OGTT at 24-28 weeks of the previous pregnancy,BMI≥24 kg·m^(-2) before re-pregnant,family history of DM,and hypothyroidism before re-pregnant are the risk factors of abnormal glucose metabolism in re-pregnant patients with GDM.

关 键 词：妊娠糖尿病 糖代谢异常 再次妊娠 相关因素 

分 类 号：R587.1[医药卫生—内分泌]